Art

J-GLOBAL ID：200902246569669015   Reference number：08A0894142

Structural Elucidation of a Tadalafil Analogue Found in a Dietary Supplement

健康食品中から検出されたタダラフィル類縁物質の構造解析

Author (7)： HASEGAWA Takashi (Chiba Prefectural Inst. Public Health, Chiba, JPN) ,  SAIJO Masaaki (Chiba Prefectural Inst. Public Health, Chiba, JPN) ,  ISHII Toshiyasu (Chiba Prefectural Inst. Public Health, Chiba, JPN) ,  NAGATA Tomoko (Chiba Prefectural Inst. Public Health, Chiba, JPN) ,  HAISHIMA Yuji (National Inst Health Sci., Tokyo, JPN) ,  KAWAHARA Nobuo (National Inst Health Sci., Tokyo, JPN) ,  GODA Yukihiro (National Inst Health Sci., Tokyo, JPN)
Material： 食品衛生学雑誌  (Food Hygiene and Safety Science)
Volume： 49  Issue： 4  Page： 311-315  Publication year： Aug. 25, 2008 
JST Material Number： G0622A  ISSN： 0015-6426  CODEN： SKEZAP  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Health Food ,  structure analysis ,  *analogical material ,  detection ,  food evaluation ,  food ingredient ,  tonic ,  dietary supplement ,  isolation (separation) ,  purification ,  high performance liquid chromatography ,  Electrospray Ionization Mass Spectrometry ,  NMR ,  FT-ICR mass spectrometry ,  LC-ESI-MS ,  gastrointestinal drug ,  enzyme inhibitor

JST classification (1)： Food in general  (FJ01010Y)

Substance index (2)： Tadalafil ,  1-(1,3-Benzodioxole-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Reference (12)：

• 1) Kojima, T., Kishi, M., Sekita, S., Satake, M. Origin of sennosides in dietary supplements containing senna stem. Shokuhin Eiseigaku Zasshi (J. Food Hyg. Soc. Japan), 42, 202-205 (2001).
• 2) Kumasaka, K., Kojima, T., Honda, H., Doi, K. Screening and quantitative analysis for sulfonylurea-type oral antidiabetic agents in adulterated health food using thin-layer chromatography and high-performance liquid chromatography. J. Health Sci., 51, 453-460 (2005).
• 3) Mikami, E., Goto, T., Ohno, T., Oka, H., Kanamori, H. Simultaneous analysis of seven benzodiazepines in dietary supplements as adulterants using high performance liquid chromatography and its application to an identification system for diazepam. J. Health Sci., 51, 278-283 (2005).
• 4) Moriyasu, T., Shigeoka, S., Kishimoto, K., Ishikawa, F., Nakajima, J., Kamimura, H., Yasuda, I. Identification system for sildenafil in health foods. Yakugaku Zasshi (Journal of the Phamaceutical Society of Japan), 121, 765-769 (2001).
• 5) Moriyasu, T., Kishimoto, Nakajima, J., K., Shigeoka, S., Minowa, K., Kamimura, H., Yasuda, I. Analytical result of Chinese weight-loss supplement caused health damages. Tokyoto Kenko Anzen Kenkyu Senta Kenkyu Nenpo (Annual Report of Tokyo Metropolitan Institute of Public Health), 54, 69-73 (2003).

Terms in the title (4)： 健康食品 ,  タダラフィル ,  類縁物質 ,  構造解析