Art

J-GLOBAL ID：200902248680816127   Reference number：04A0591553

Protein-Tyrosine Phosphatase 1B Associates with Insulin Receptor and Negatively Regulates Insulin Signaling without Receptor Internalization

蛋白質チロシンホスファターゼ1Bはインシュリン受容体と結合し,受容体インターナリゼーションなしにインシュリンシグナル伝達を負調節する

Author (7)： SHI K (Shiga Univ. Medical Sci., Otsu) ,  EGAWA K (Shiga Univ. Medical Sci., Otsu) ,  MAEGAWA H (Shiga Univ. Medical Sci., Otsu) ,  NAKAMURA T (Shiga Univ. Medical Sci., Otsu) ,  UGI S (Shiga Univ. Medical Sci., Otsu) ,  NISHIO Y (Shiga Univ. Medical Sci., Otsu) ,  KASHIWAGI A (Shiga Univ. Medical Sci., Otsu)
Material： Journal of Biochemistry  (J Biochem)
Volume： 136  Issue： 1  Page： 89-96  Publication year： Jul. 01, 2004 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *protein tyrosine phosphatase ,...
Semi thesaurus term： *cellular signal transduction ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=04A0591553&from=J-GLOBAL&jstjournalNo=F0286A") }}

JST classification (3)： Enzyme physiology  (EJ02020P) ,  Receptors on cell membrane  (EF04030C) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Monodansyl cadaverine

Reference (26)：

• AHMAD, F. Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway. J. Biol. Chem. 1995, 270, 20503-20508
• ELCHEBLY, M. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science. 1999, 283, 1544-1548
• KLAMAN, L. D. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell. Biol. 2000, 20, 5479-5489
• MAEGAWA, H. Thiazolidine derivatives Ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities. J. Biol. Chem. 1995, 270, 7724-7730
• EGAWA, K. Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in L6 myocytes and Fao hepatoma cells. J. Biol. Chem. 2001, 276, 10207-10211

Terms in the title (6)： 蛋白質チロシンホスファターゼ1B ,  インシュリン受容体 ,  受容体インターナリゼーション ,  インシュリン ,  シグナル伝達 ,  調節