Art

J-GLOBAL ID：200902251420844853   Reference number：03A0136823

Molecular targeting therapy of cancer: Drug resistance, apoptosis and survival signal.

癌の分子標的療法 薬物耐性,アポトーシス及び生存シグナル

Author (7)： TSURUO T (Univ. Tokyo, Tokyo) ,  NAITO M (Univ. Tokyo, Tokyo) ,  TOMIDA A (Univ. Tokyo, Tokyo) ,  FUJITA N (Univ. Tokyo, Tokyo) ,  MASHIMA T (Japanese Foundation for Cancer Res., Tokyo) ,  SAKAMOTO H (Univ. Tokyo, Tokyo) ,  HAGA N (Univ. Tokyo, Tokyo)
Material： Cancer Science  (Cancer Sci)
Volume： 94  Issue： 1  Page： 15-21  Publication year： Jan. 2003 
JST Material Number： F0633A  ISSN： 1347-9032  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tumor ,...
Semi thesaurus term： MDR1遺伝子

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Methylglyoxal

Reference (50)：

• TSURUO, T. Mechanisms of multidrug resistance and implications for therapy. Jpn J Caner Res. 1988, 79, 285-296
• SUGIMOTO, Y. DNA-mediated transfer and cloning of a human multidrug-resistant gene of Adriamycin-resistant myelogenous leukemia K562. Cancer Res. 1987, 47, 2620-2625
• HAMADA, H. Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies. Proc Natl Acad Sci USA. 1986, 83, 7785-7789
• HAMADA, H. Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. J Biol Chem. 1988, 263, 1454-1458
• NAITO, M. ATP/Mg^<2+>-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells. J Biol Chem. 1988, 263, 11887-11891

Terms in the title (6)： 癌 ,  分子標的療法 ,  薬物耐性 ,  アポトーシス ,  生存 ,  シグナル