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J-GLOBAL ID：200902251870409774   Reference number：09A0301483

ONE-POT SYNTHESIS OF 6-SUBSTITUTED AMINO-2,4-DIAMINOPYRIMIDINE DERIVATIVES USING KETENE DITHIOACETALS WITH AMINES AND GUANIDINE CARBONATE

ケテンジチオアセタール類,アミンと炭酸グアニジンとを用いる6-置換アミノ-2,4-ジアミノピリミジン誘導体のワンポット合成

Author (6)： HIROSE Miki (Nagasaki Univ., Nagasaki) ,  HAGIMORI Masayori (Nagasaki International Univ., Sasebo) ,  SHIGEMITSU Yasuhiro (Technol. Center of Nagasaki, Nagasaki, JPN) ,  MIZUYAMA Naoko (Saga Univ. Hospital, Saga) ,  WANG Bo-Cheng (Tamkang Univ., Tamsui, TWN) ,  TOMINAGA Yoshinori (Nagasaki Univ., Nagasaki)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 78  Issue： 4  Page： 899-903  Publication year： Apr. 01, 2009 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,  one-pot synthesis ,  *cyclization reaction ,  phosphor ,  *Pyrimidines

JST classification (2)： Pyrimidines  (CF07103W) ,  Cyclization reaction,ring-opening reaction  (CF02050I)

Substance index (12)： 2,4-Diamino-6-(1-phenylethylamino)pyrimidine-5-carbonitrile ,  2,4-Diamino-6-(2-methoxyanilino)pyrimidine-5-carbonitrile ,  2,4-Diamino-6-(3-methoxyanilino)pyrimidine-5-carbonitrile ,  2,4-Diamino-6-(4-chloroanilino)pyrimidine-5-carbonitrile ,  2,4-Diamino-6-(4-methoxyanilino)pyrimidine-5-carbonitrile ,  2,4-Diamino-6-(benzylamino)pyrimidine-5-carbonitrile ,  2,4-Diamino-6-anilinopyrimidine-5-carbonitrile ,  2,4-Diamino-6-pyrrolizinopyrimidine-5-carbonitrile ,  2,4-Diamino-6-morpholinopyrimidine-5-carbonitrile ,  2-Amino-4-anilino-5H-indeno[1,2-d]pyrimidine-5-one ,  2-Amino-4-hydroxy-6-(benzylamino)pyrimidine-5-carbonitrile ,  Phenyl[2,4-diamino-6-(benzylamino)pyrimidine-5-yl] sulfone

Reference (12)：

• (a) Y. Tominaga and Y. Matsuda, J. Heterocycl. Chem., 1985, 22, 937;(b) Y. Tominaga and Y. Matsuda, Yuki Gousei Kyoukaishi (J. Synth. Org. Chem. Japan), 1985, 43, 669;(c) Y. Tominaga, Yuki Gousei Kyoukaishi (J. Synth. Org. Chem. Japan), 1989, 47, 413;(d) Y. Tominaga, Trends in Heterocyclic Chemistry, 1991, 2, 43;(e) Y. Tominaga, Y. Shigemitsu, and K. Sasaki, J. Heterocycl. Chem., 2002, 39, 571.
• (a) R. L. Shriner and F. W. Newmann, Chem. Rev., 1944, 35, 351;(b) D. J. Brown,‘Pyrimidines and Their Benzo Derivatives in Comprehensive Heterocyclic Chemistry,’ in Vol.3, ed. by A. R. Katrizky and C. W. Rees, Pergamon Press, Oxford, 1984, p.57, p.443;(c) H. Yamanaka and T. Sakamoto, Yuki Gousei Kagaku Kyoukaishi (J. Synth. Org, Chem. Japan), 1985, 43, 951.
• (a) F. A. El-Essay, N. R. El-Brollosy, and E. B. Pedwesen, J. Heterocycl. Chem., 2003, 40, 213;(b) G. Wollein and R. Troschutz, J. Heterocycl. Chem., 2002, 39, 1195.
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Terms in the title (8)： ケテン ,  ジチオアセタール類 ,  アミン ,  炭酸 ,  グアニジン ,  置換アミノ ,  誘導体 ,  ワンポット合成