Art

J-GLOBAL ID：200902251986211955   Reference number：04A0795077

Cardiovascular Effects of an L/N-type Ca²⁺ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs

慢性心房心室伝導ブロックイヌで評価したL/N型Ca²⁺チャンネルブロッカー,シルニジピンの心血管効果

Author (5)： TAKAHARA A (Ajinomoto Co., Inc., Kawasaki, JPN) ,  SUGIYAMA A (Univ. Yamanashi, Yamanashi, JPN) ,  SATOH Y (Univ. Yamanashi, Yamanashi, JPN) ,  NAKAMURA Y (Univ. Yamanashi, Yamanashi, JPN) ,  HASHIMOTO K (Univ. Yamanashi, Yamanashi, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 96  Issue： 2  Page： 219-223  Publication year： Oct. 20, 2004 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *calcium antagonist ,...
Semi thesaurus term： sympathetic nerve ,...

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JST classification (1)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (1)： FRC-8653

Reference (15)：

• 1 Uneyama H, Uchida H, Konda T, Yoshimoto R. Cilnidipine: Preclinical profile and clinical evaluation. Cardiovasc Drug Rev. 1999;17:341–357.
• 2 Uneyama H, Takahara A, Dohmoto H, Yoshimoto R, Inoue K, Akaike N. Blockade of N-type Ca²⁺ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones. Br J Pharmacol. 1997;122:37–42.
• 3 Takahara A, Koganei H, Takeda T, Iwata S. Antisympathetic and hemodynamic property of a dual L/N-type Ca²⁺ channel blocker cilnidipine in rats. Eur J Pharmacol. 2002;434:43–47.
• 4 Sakata K, Shirotani M, Yoshida H, Nawada R, Obayashi K, Togi K, et al. Effects of amlodipine and cilnidipine on cardiac sympathetic nervous system and neurohormonal status in essential hypertension. Hypertension. 1999;33:1447–1452.
• 5 Konda T, Takahara A, Maeda K, Dohmoto H, Yoshimoto R. Effects of a dual L/N-type Ca²⁺ channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs. Eur J Pharmacol. 2001;413:117–120.

Terms in the title (10)： 慢性 ,  心房 ,  心室 ,  伝導ブロック ,  イヌ ,  評価 ,  N型Ca2+チャンネル ,  ブロッカー ,  シルニジピン ,  心血管効果