Art

J-GLOBAL ID：200902252491556430   Reference number：09A0715629

Enantioselective total synthesis of atpenin A5

アトペニンA5のエナンチオ選択性全合成

Author (7)： OHTAWA Masaki (Kitasato Univ., Tokyo, JPN) ,  OGIHARA Satoru (Kitasato Univ., Tokyo, JPN) ,  SUGIYAMA Kouhei (Kitasato Univ., Tokyo, JPN) ,  SHIOMI Kazuro (Kitasato Univ., Tokyo, JPN) ,  HARIGAYA Yoshihiro (Kitasato Univ., Tokyo, JPN) ,  NAGAMITSU Tohru (Kitasato Univ., Tokyo, JPN) ,  OMURA Satoshi (Kitasato Univ., Tokyo, JPN)
Material： Journal of Antibiotics  (J Antibiot)
Volume： 62  Issue： 6  Page： 289-294  Publication year： Jun. 2009 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： enzyme inhibitor ,...
Semi thesaurus term： *エナンチオ選択性全合成 ,...

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JST classification (1)： Synthesis of drugs  (GV01030F)

Substance index (1)： Atpenin A5

Reference (13)：

• OMURA, S. Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties. J. Antibiot. 1988, 41, 1769-1773
• OSHINO, K. Mechanism of action of atpenin B on Raji cells. J. Antibiot. 1990, 43, 1064-1068
• KUMAGAI, H. The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp. J. Antibiot. 1990, 43, 1553-1558
• TRECOURT, F. Total synthesis of (±)-Atpenin B. An original 'Clockwise' functionalization of 2-chloropyridine. J. Org. Chem. 1994, 59, 6173-6178
• MIYADERA, H. Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). Proc. Natl Acad. Sci. USA. 2003, 100, 473-477

Terms in the title (3)： アトペニンA5 ,  エナンチオ選択性 ,  全合成