Art

J-GLOBAL ID：200902256540925050   Reference number：09A0740029

Postischemic administration of angiotensin II type 1 receptor blocker reduces cerebral infarction size in hypertensive rats

アンギオテンシンIIタイプI受容体拮抗薬の虚血後投与は高血圧ラットの脳梗塞サイズを減少させる

Author (9)： OMURA-MATSUOKA Emi (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  YAGITA Yoshiki (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  SASAKI Tsutomu (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  TERASAKI Yasukazu (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  OYAMA Naoki (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  SUGIYAMA Yukio (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  OKAZAKI Shuhei (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  SAKODA Saburo (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  KITAGAWA Kazuo (Osaka Univ. Graduate School of Medicine, Osaka, JPN)
Material： Hypertension Research  (Hypertens Res)
Volume： 32  Issue： 7  Page： 548-553  Publication year： Jul. 2009 
JST Material Number： Y0303A  ISSN： 0916-9636  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： spontaneously hypertensive rat ,...
Semi thesaurus term： angiotensin II type1 receptor antagonist ,...

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JST classification (2)： Basic research of other drugs acting on central nervous system  (GW03120U) ,  Central nervous system  (EJ12030F)

Substance index (1)： Candesartan

Reference (30)：

• ADAMS, HP Jr. Guidelines for the early management of adults with ischemic stroke. Stroke. 2007, 38, 1655-1711
• ENGELHORN, T. The angiotensin II type 1-receptor blocker candesartan increases cerebral blood flow, reduces infarct size, and improves neurologic outcome after transient cerebral ischemia in rats. J Cereb Blood Flow Metab. 2004, 24, 467-474
• HOSOMI, N. Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Neuroscience. 2005, 234, 225-231
• FAGAN, SC. Hypertension after experimental cerebral ischemia : candesartan provides neurovascular protection. J Hypertens. 2006, 24, 535-539
• BRDON, J. Comparison between early and delayed systemic treatment with candesartan of rats after ischemic stroke. J Hypertens. 2007, 25, 187-196

Terms in the title (8)： アンギオテンシンII ,  タイプ ,  受容体拮抗薬 ,  虚血 ,  投与 ,  高血圧ラット ,  脳梗塞 ,  サイズ