Art

J-GLOBAL ID：200902256850326947   Reference number：08A1243245

Convenient One-Pot Synthesis of 2-Oxazolines from Carboxylic Acids

カルボン酸からの2-オキサゾリン類の簡便ワンポット合成

Author (7)： HIOKI Kazuhito (Fac. of Pharmaceutical Sciences, Kobe Gakuin Univ.) ,  HIOKI Kazuhito (Life Sci. Center, Kobe Gakuin Univ.) ,  TAKECHI Yumiko (Fac. of Pharmaceutical Sciences, Kobe Gakuin Univ.) ,  KIMURA Noriyo (Fac. of Pharmaceutical Sciences, Kobe Gakuin Univ.) ,  TANAKA Hiroyuki (Fac. of Pharmaceutical Sciences, Inst. of Medical, Pharmaceutical, and Health Sciences, Kanazawa Univ.) ,  KUNISHIMA Munetaka (Fac. of Pharmaceutical Sciences, Inst. of Medical, Pharmaceutical, and Health Sciences, Kanazawa Univ.) ,  KUNISHIMA Munetaka (Life Sci. Center, Kobe Gakuin Univ.)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 56  Issue： 12  Page： 1735-1737 (J-STAGE)  Publication year： 2008 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *oxygen heterocyclic compound ,  *nitrogen heterocyclic compound ,  one-pot synthesis ,  amidation ,  cyclization reaction ,  potassium hydroxide ,  reaction mechanism ,  aromatic compound ,  olefin compound ,  unsaturated carboxylic acid ,  carboxylic acid ,  alicyclic compound ,  aromatic carboxylic acid

JST classification (1)： Oxazoles,isoxazoles  (CF07080Y)

Substance index (20)： Cinnamic acid ,  2-Chloroethylamine ,  2-Phenylpropionic acid ,  2-Bromoethylamine ,  3-Phenylpropionic acid ,  4-Pentenoic acid ,  Boc-Phenylalanine ,  Cyclohexanecarboxylic acid ,  Benzoic Acid ,  DMT-MM ,  2-Phenethyl-2-oxazoline ,  2-Bromoethylammonium bromide ,  2-Chloroethylammonium chloride ,  2-(α-Methylbenzyl)-2-oxazoline ,  2-(3-Butenyl)-2-oxazoline ,  2-Styryl-2-oxazoline ,  2-[N-(tert-Butoxycarbonyl)-L-phenylalanyl]-2-oxazoline ,  (4S)-2-Phenethyl-4-isopropyl-2-oxazoline ,  N-Carbobenzyloxy-L-phenylalanine ,  (4S)-2-[(S)-α-(Benzyloxycarbonylamino)phenethyl]-4-isopropyl-2-oxazoline

Reference (25)：

• 1) Gant T. G., Meyers A. I., Tetrahedron, 50, 2297—2360 (1994).
• 2) Reuman M., Meyers A. I., Tetrahedron, 41, 837—860 (1985).
• 3) Meyers A. I., Mihelich E. D., Angew. Chem., 88, 321—332 (1976).
• 4) Frump J. A., Chem. Rev., 71, 483—506 (1971).
• 5) Wiley R. H., Bennett L. L. Jr., Chem. Rev., 44, 447—476 (1949).

Terms in the title (4)： カルボン酸 ,  2-オキサゾリン ,  簡便 ,  ワンポット合成