Art

J-GLOBAL ID：200902257505135094   Reference number：08A0602598

The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis: A prospective, multicenter study

原発性胆汁性肝硬変に対するウルソデオキシコール酸とベザフィブレート併用療法の有効性 前向き多施設試験

Author (12)： IWASAKI Shinji (Kochi Medical School, Kochi) ,  OHIRA Hiromasa (Fukushima Medical Univ. School of Medicine, Fukushima) ,  NISHIGUCHI Shuhei (Hyogo Coll. of Medicine, Nishinomiya) ,  ZENIYA Mikio (Jikei Univ. School of Medicine, Tokyo) ,  KANEKO Shuichi (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa) ,  ONJI Morikazu (Ehime Univ. Graduate School of Medicine, Toon) ,  ISHIBASHI Hiromi (NHO Nagasaki Medical Center, Omura) ,  SAKAIDA Isao (Yamaguchi Univ. Graduate School of Medicine, Ube) ,  KURIYAMA Shigeki (Kagawa Univ. Fac. of Medicine, Kagawa) ,  ICHIDA Takafumi (Juntendo Univ. School of Medicine Shizuoka Hospital, Izunokuni) ,  ONISHI Saburo (Kochi Medical School, Kochi) ,  TODA Gotaro (Senpo Tokyo Takanawa Hospital, Tokyo, JPN)
Material： Hepatology Research  (Hepatol Res)
Volume： 38  Issue： 6  Page： 557-564  Publication year： Jun. 2008 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： RCT

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JST classification (2)： Clinical application of drugs acting on digestive system  (GW09020B) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Substance index (2)： Ursodeoxycholic Acid ,  Bezafibrate

Reference (22)：

• POUPON, RE. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBA Study Group. N Engl J Med. 1991, 30, 1548-1554
• LINDOR, KD. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology. 1994, 106, 1284-1290
• TER BORG, PC. Prognosis of ursodeoxycholic acid-treated patients with primary biliary cirrhosis. Results of a 10-yr cohort study involving 297 patients. Am J Gastroenterol. 2006, 10, 2044-2050
• SHI, J. Long-term effects of mid-dose ursodeoxycholic acid in primary biliary cirrhosis : a meta-analysis of randomized controlled trials. Am J Gastroenterol. 2006, 101, 1529-1538
• CORPECHOT, C. Primary biliary cirrhosis : incidence and predictive factors of cirrhosis development in ursodiol-treated patients. Gastroenterology. 2002, 122, 652-658

Terms in the title (6)： 原発性胆汁性肝硬変 ,  ウルソデオキシコール酸 ,  ベザフィブレート ,  併用療法 ,  有効性 ,  多施設試験