Art

J-GLOBAL ID：200902262123238385   Reference number：06A0055787

アルツハイマー病の分子病態と治療への展望

Author (1)： IWATSUBO TAKESHI (東大 大学院薬学系研究科)
Material： 日本老年医学会雑誌  (Japanese Journal of Geriatrics)
Volume： 42  Issue： 6  Page： 651-654  Publication year： Nov. 25, 2005 
JST Material Number： Z0680A  ISSN： 0300-9173  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *Alzheimer Disease ,...
Semi thesaurus term： Drosophila ,...

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JST classification (1)： Basic neurology  (GN01020W)

Reference (4)：

• IWATSUBO, T. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ-monoclonals : Evidence that an initially deposited species is Aβ42(43). Neuron. 1994, 13, 45-53
• TOMITA, T. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA. 1997, 94, 2025-2030
• TAKASUGI, N. The role of presenilin cofactors in the γ-secretase complex. Nature. 2003, 422, 438-441
• TAKAHASHI, Y. Sulindac sulfide is a non-competitive γ-secretase inhibitor that preferentially reduces Aβ42 generation. J Biol Chem. 2003, 278, 18664-18670

Terms in the title (4)： アルツハイマー ,  分子病態 ,  治療 ,  展望