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J-GLOBAL ID：200902264574210118   Reference number：04A0890231

Structure-Activity Relationship of S-Benzylisothiourea Derivatives to Induce Spherical Cells in Escherichia coli

Escherichia coliにおける球形細胞を誘導するS-ベンジルイソチオ尿素誘導体の構造活性相関

Author (6)： IWAI N (Tokyo Inst. Technol., Yokohama, JPN) ,  EBATA T (Tokyo Inst. Technol., Yokohama, JPN) ,  NAGURA H (Tokyo Inst. Technol., Yokohama, JPN) ,  KITAZUME T (Tokyo Inst. Technol., Yokohama, JPN) ,  NAGAI K (Chubu Univ., Aichi, JPN) ,  WACHI M (Tokyo Inst. Technol., Yokohama, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 68  Issue： 11  Page： 2265-2269  Publication year： Nov. 23, 2004 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Escherichia coli ,...

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JST classification (1)： Microorganism physiology in general  (EG03051L)

Substance index (9)： S-Ethylisothiourea ,  Benzyl thiocyanate ,  Benzyl isothiocyanate ,  1-Phenylthiourea ,  RRD-251 ,  2-(4-Chlorobenzyl)isothiourea ,  2-Benzylisothiourea ,  2-(Cyclohexylmethyl)isothiourea ,  2-Heptylisothiourea

Reference (13)：

• 1) Wachi, M., Iwai, N., Kunihisa, A., and Nagai, K., Irregular nuclear localization and anucleate cell production in Escherichia coli induced by a Ca²⁺ chelator, EGTA. Biochimie, 81, 909–913 (1999).
• 2) Iwai, N., Nagai, K., and Wachi, M., Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. Biosci. Biotechnol. Biochem., 66, 2658–2662 (2002).
• 3) Tamaki, S., Matsuzawa, H., and Matsuhashi, M., Cluster of mrdA and mrdB genes responsible for the rod shape and mecillinam sensitivity of Escherichia coli. J. Bacteriol., 141, 52–57 (1980).
• 4) Spratt, B. G., Escherichia coli resistance to β-lactam antibiotics through a decrease in the affinity of a target for lethality. Nature, 274, 713–715 (1978).
• 5) Ishino, F., Park, W., Tomioka, S., Tamaki, S., Takase, I., Kunugita, K., Matsuzawa, H., Asoh, S., Ohta, T., Spratt, B. G., and Matsuhashi, M., Peptidoglycan synthesis activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and RodA protein. J. Biol. Chem., 261, 7024–7031 (1986).

Terms in the title (7)： Escherichia ,  球形 ,  細胞 ,  誘導 ,  S-ベンジルイソチオ尿素 ,  誘導体 ,  構造活性相関