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J-GLOBAL ID：200902266202192248   Reference number：08A0306973

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans

電離放射線はヒトの小頭症に責任のある遺伝子ASPMを下方調節する

Author (12)： FUJIMORI Akira (Cellular and Molecular Biology Team, National Inst. of Radiological Sciences, Heavy-Ion Radiobiology Res. Group ...) ,  YAOI Takeshi (Dep. of Pathology and Applied Neurobiology, Kyoto Prefectural Univ. of Medicine, Graduate School of Medical Sciences ...) ,  OGI Hiroshi (Dep. of Pathology and Applied Neurobiology, Kyoto Prefectural Univ. of Medicine, Graduate School of Medical Sciences ...) ,  WANG Bing (National Inst. of Radiological Sciences, Heavy-Ion Radiology Res. Group, Res. Center for Charged Particle Therapy ...) ,  SUETOMI Katsutoshi (Cellular and Molecular Biology Team, National Inst. of Radiological Sciences, Heavy-Ion Radiobiology Res. Group ...) ,  SEKINE Emiko (Cellular and Molecular Biology Team, National Inst. of Radiological Sciences, Heavy-Ion Radiobiology Res. Group ...) ,  YU Dong (Cellular and Molecular Biology Team, National Inst. of Radiological Sciences, Heavy-Ion Radiobiology Res. Group ...) ,  KATO Takamitsu (Cellular and Molecular Biology Team, National Inst. of Radiological Sciences, Heavy-Ion Radiobiology Res. Group ...) ,  TAKAHASHI Sentaro (National Inst. of Radiological Sciences, Heavy-Ion Radiology Res. Group, Res. Center for Charged Particle Therapy ...) ,  OKAYASU Ryuichi (Cellular and Molecular Biology Team, National Inst. of Radiological Sciences, Heavy-Ion Radiobiology Res. Group ...) ,  ITOH Kyoko (Dep. of Pathology and Applied Neurobiology, Kyoto Prefectural Univ. of Medicine, Graduate School of Medical Sciences ...) ,  FUSHIKI Shinji (Dep. of Pathology and Applied Neurobiology, Kyoto Prefectural Univ. of Medicine, Graduate School of Medical Sciences ...)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 369  Issue： 3  Page： 953-957  Publication year： May. 09, 2008 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *ionizing radiation ,  *Microcephaly ,  human ,  *gene ,  gene expression ,  fibroblast ,  Down-Regulation ,  Mus musculus ,  target ,  neural stem cell ,  Neurosphere ,  molecular genetic phenomenon ,  Myomorpha
Semi thesaurus term： *ASPM遺伝子

JST classification (2)： Influence on animals  (EE04040K) ,  Congenital diseases,deformities in general.  (GD03010V)

Terms in the title (6)： 電離放射線 ,  ヒト ,  小頭症 ,  責任 ,  遺伝子 ,  下方調節