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J-GLOBAL ID：200902268553502432   Reference number：03A0840968

cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells

cGMPはヒトさい静脈上皮細胞におけるGPTシクロヒドロラーゼI活性とテトラヒドロビオプテリン生合成を阻害する

Author (9)： SHIRAISHI H (Fujita Health Univ., Aichi, JPN) ,  KATO T (Fujita Health Univ., Aichi, JPN) ,  ATSUTA K (Fujita Health Univ., Aichi, JPN) ,  SUMI(ICHINOSE) C (Fujita Health Univ., Aichi, JPN) ,  OHTSUKI M (Fujita Health Univ., Aichi, JPN) ,  ITOH M (Fujita Health Univ., Aichi, JPN) ,  HISHIDA H (Fujita Health Univ., Aichi, JPN) ,  TADA S (Fujita Health Univ., Aichi, JPN) ,  UDAGAWA Y (Fujita Health Univ., Aichi, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 93  Issue： 3  Page： 265-271  Publication year： Nov. 01, 2003 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cyclic nucleotide ,...
Semi thesaurus term： cellular signal transduction

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Immunological reaction in general  (ED03010T)

Substance index (2)： cGMP ,  Tetrahydrobiopterin

Reference (35)：

• 1 Hattori Y, Akimoto K, Nakanishi N, Kasai K. Glucocorticoid regulation of nitric oxide and tetrahydrobiopterin in rat model of endotoxic shock. Biochem Biophys Res Commun. 1997;240:298–303.
• 2 Vann LR, Twitty S, Spiegel S, Milstien S. Divergence in regulation of nitric-oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-α. J Biol Chem. 2000;275:13275–13281.
• 3 Gross SS, Levi R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem. 1992;267:25722–25729.
• 4 Hattori Y, Gross SS. GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase. Biochem Biophys Res Commun. 1993;195:435–441.
• 5 Nakayama DK, Geller DA, Disilvio M, et al. Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. Am J Physiol. 1994;266:L455–L460.

Terms in the title (9)： cGMP ,  ヒト ,  さい静脈 ,  上皮細胞 ,  GPT ,  活性 ,  テトラヒドロビオプテリン ,  生合成 ,  阻害