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J-GLOBAL ID：200902274450331222   Reference number：06A0965092

Characterization of Heme-Coordinating Histidyl Residues of Cytochrome b₅ Based on the Reactivity with Diethylpyrocarbonate: A Mechanism for the Opening of Axial Imidazole Rings

ジエチルピロカルボナートとの反応性に基づいたチトクロームb₅のヘム配位ヒスチジル残基の特性化:アキシアルイミダゾール環の開環に対する機構

Author (7)： NAKANISHI Nobuyuki (Kobe Univ., Hyogo) ,  TAKEUCHI Fusako (Kobe Univ., Hyogo) ,  OKAMOTO Hidetsugu (Kobe Univ., Hyogo) ,  TAMURA Atsuo (Kobe Univ., Hyogo) ,  HORI Hiroshi (Osaka Univ., Osaka) ,  TSUBAKI Motonari (Kobe Univ., Hyogo) ,  TSUBAKI Motonari (JST-CREST)
Material： Journal of Biochemistry  (J Biochem)
Volume： 140  Issue： 4  Page： 561-571  Publication year： Oct. 01, 2006 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cytochrome b5 ,...
Semi thesaurus term： Imidazoles ,...

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JST classification (1)： Proteins and peptides in general  (EB03010N)

Substance index (1)： Diethyl pyrocarbonate

Reference (37)：

• IVERSON, T. M. Heme packing motifs revealed by the crystal structure of the tetra-haem cytochrome c554 from Nitrosomonas europaea. Nat. Struct. Biol. 1998, 5, 1005-1012
• ROTSAERT, F. A. J. Biophysical and structural analysis of a novel heme b iron ligation in the flavocytochrome cellobiose dehydrogenase. J. Biol. Chem. 2003, 278, 33224-33231
• UNO, T. Inversion of axial coordination in myoglobin to create a "proximal" ligand binding pocket. Biochemistry. 2003, 42, 10191-10199
• DOU, Y. Alteration of axial coordination by protein engineering in myoglobin Bisimidazole ligation in the His^<64>→Val/Val^<68>→His double mutant. J. Biol. Chem. 1995, 270, 15993-16001
• BARRICK, D. Replacement of the proximal ligand of sperm whale myoglobin with free imidazole in the mutant His-93→Gly. Biochemistry. 1994, 33, 6546-6554

Terms in the title (8)： ジエチルピロカルボナート ,  反応性 ,  チトクロームb5 ,  ヘム ,  残基 ,  特性化 ,  環 ,  開環