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J-GLOBAL ID：200902274689011505   Reference number：05A1036352

The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β

ALK-5阻害剤,A-83-01は形質転換成長因子-βによるSmadシグナリングおよび上皮から間葉への遷移を阻害する

Author (10)： TOJO Masayoshi (Japanese Foundation for Cancer Res. (JFCR), Tokyo, JPN) ,  TOJO Masayoshi (Univ. Tokyo, Tokyo, JPN) ,  HAMASHIMA Yoshio (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  HANYU Aki (Japanese Foundation for Cancer Res. (JFCR), Tokyo, JPN) ,  KAJIMOTO Tetsuya (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  SAITOH Masao (Univ. Tokyo, Tokyo, JPN) ,  MIYAZONO Kohei (Japanese Foundation for Cancer Res. (JFCR), Tokyo, JPN) ,  MIYAZONO Kohei (Univ. Tokyo, Tokyo, JPN) ,  NODE Manabu (Kyoto Pharmaceutical Univ., Kyoto, JPN) ,  IMAMURA Takeshi (Japanese Foundation for Cancer Res. (JFCR), Tokyo, JPN)
Material： Cancer Science  (Cancer Sci)
Volume： 96  Issue： 11  Page： 791-800  Publication year： Nov. 2005 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *TGF beta ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (1)： Experimental treatment for tumors  (GE02040Y)

Substance index (1)： A-83-01

Reference (27)：

• DERYNCK, R. TGF-β signaling in tumor suppression and cancer progression. Nat Genet. 2001, 29, 117-129
• MIYAZONO, K. Regulation of TGF-β signaling and its roles in progression of tumors. Cancer Sci. 2003, 94, 230-234
• HELDIN, CH. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature. 1997, 390, 465-471
• SHI, Y. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell. 2003, 113, 685-700
• MIYAZAWA, K. Two major Smad pathways in TGF-β superfamily signaling. Genes Cells. 2002, 7, 1191-1204

Terms in the title (10)： ALK-5 ,  阻害剤 ,  A-83-01 ,  形質転換成長因子 ,  SMAD ,  シグナリング ,  上皮 ,  間葉 ,  遷移 ,  阻害