Art

J-GLOBAL ID：200902275474614418   Reference number：08A0801113

DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts

新規のNF-κB阻害因子であるDHMEQはケロイド線維芽細胞において増殖およびI型コラーゲン蓄積を抑制する

Author (10)： MAKINO Sachio (Div. of Plastic and Reconstructive Surgery, Dep. of Developmental and Reconstructive Medicine, Nagasaki Univ. ...) ,  MITSUTAKE Norisato (Dep. of Molecular Medicine, Atomic Bomb Disease Inst., Nagasaki Univ. Graduate School of Biomedical Sciences, 1-12-4 ...) ,  NAKASHIMA Masahiro (Tissue and Histopathology Section, Div. of Scientific Data Registry, Atomic Bomb Disease Inst., Nagasaki Univ. ...) ,  SAENKO Vladimir A. (Dep. of International Health and Radiation Res., Atomic Bomb Disease Inst., Nagasaki Univ. Graduate School of ...) ,  OHTSURU Akira (Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki Univ. Hospital, Nagasaki, JPN) ,  UMEZAWA Kazuo (Dep. of Applied Chemistry, Fac. of Sci. and Technol., Keio Univ., Yokohama, JPN) ,  TANAKA Katsumi (Div. of Plastic and Reconstructive Surgery, Dep. of Developmental and Reconstructive Medicine, Nagasaki Univ. ...) ,  HIRANO Akiyoshi (Div. of Plastic and Reconstructive Surgery, Dep. of Developmental and Reconstructive Medicine, Nagasaki Univ. ...) ,  YAMASHITA Shunichi (Dep. of Molecular Medicine, Atomic Bomb Disease Inst., Nagasaki Univ. Graduate School of Biomedical Sciences, 1-12-4 ...) ,  YAMASHITA Shunichi (Dep. of International Health and Radiation Res., Atomic Bomb Disease Inst., Nagasaki Univ. Graduate School of ...)
Material： Journal of Dermatological Science  (J Dermatol Sci)
Volume： 51  Issue： 3  Page： 171-180  Publication year： Sep. 2008 
JST Material Number： W1280A  ISSN： 0923-1811  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： NF-kappaB ,...
Semi thesaurus term： *NF.KAPPA.B inhibitor

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JST classification (1)： Basic research of drugs acting on integumentum commune  (GW12010Y)

Substance index (1)： (-)-DHMEQ

Reference (36)：

• AL-ATTAR, A. Keloid pathogenesis and treatment. Plast Reconstr Surg. 2006, 117, 286-300
• ATIYEH, BS. Keloid or hypertrophic scar : the controversy : review of the literature. Ann Plast Surg. 2005, 54, 676-680
• GHOSH, S. NF-kappa B and Rel proteins : evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 1998, 16, 225-260
• LUO, JL. IKK/NF-kappaB signaling : balancing life and death-a new approach to cancer therapy. J Clin Invest. 2005, 115, 2625-2632
• PAHL, HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene. 1999, 18, 6853-6866

Terms in the title (8)： NF-κB ,  阻害因子 ,  DHMEQ ,  ケロイド ,  線維芽細胞 ,  増殖 ,  I型コラーゲン ,  蓄積