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J-GLOBAL ID：200902276956608470   Reference number：08A0871907

Cotylenin A, a new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2

新しい分化誘導物質コチレニンAとラパマイシンによるサイクリンG2の誘導を通した癌細胞成長の協同的抑制

Author (3)： KASUKABE Takashi (Saitama Cancer Center, Saitama) ,  OKABE-KADO Junko (Saitama Cancer Center, Saitama) ,  HONMA Yoshio (Shimane Univ., Izumo, JPN)
Material： Cancer Science  (Cancer Sci)
Volume： 99  Issue： 8  Page： 1693-1698  Publication year： Aug. 2008 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *differentiation inducing factor ,...
Semi thesaurus term： コチレニンA ,...

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JST classification (2)： Tumors(=neoplasms)of female genitalia and fetus  (GS04000K) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (2)： Doxycycline ,  Rapamycin

Reference (24)：

• SASSA, T. Isolation of new plant growth substance with cytokinin-like activity. Nature. 1970, 227, 379
• SASSA, T. Structural confirmation of cotylenin A, novel fusicoccane-diterpene glycoside with potent plant growth-regulating activity from Cladosporium fungus sp. 501-7W. Biosci Biotechnol Biochem. 1998, 62, 1815-1818
• ASAHI, K. Cotylenin A, a plant-growth regulator, induces differentiation in murine and human myeloid leukemia cells. Biochem Biophys Res Commun. 1997, 238, 758-763
• YAMAMOTO-YAMAGUCHI, Y. Induction of monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator. Br J Haematol. 2001, 112, 697-705
• HONMA, Y. Cotylenin A-a plant growth regulator as a differentiation-inducing agent against myeloid leukemia. Leuk Lymphoma. 2002, 43, 1169-1178

Terms in the title (8)： 分化 ,  コチレニンA ,  ラパマイシン ,  サイクリンG2 ,  誘導 ,  癌細胞 ,  成長 ,  協同