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J-GLOBAL ID：200902277434229190   Reference number：08A1195551

Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system

ミトコンドリアのDNA修復システムの阻害による扁平上皮癌のアポトーシスの促進

Author (5)： UETA Eisaku (Kochi Univ., Kochi, JPN) ,  SASABE Eri (Kochi Univ., Kochi, JPN) ,  YANG Zhu (Kochi Univ., Kochi, JPN) ,  OSAKI Tokio (Kochi Univ., Kochi, JPN) ,  YAMAMOTO Tetsuya (Kochi Univ., Kochi, JPN)
Material： Cancer Science  (Cancer Sci)
Volume： 99  Issue： 11  Page： 2230-2237  Publication year： Nov. 2008 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *DNA ,...
Semi thesaurus term： *DNA, Mitochondrial ,...

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JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Molecular genetics in general  (EC02010J) ,  Cell physiology in general  (EF02010S)

Substance index (1)： 8-Hydroxy-2'-deoxyguanosine

Reference (44)：

• KIM, R. The role of apoptosis in cancer cell survival and therapeutic outcome. Cancer Biol Ther. 2006, 5, 1429-1442
• CHAN, DC. Mitochondria : dynamic organelles in disease, aging, and development. Cell. 2006, 125, 1241-1252
• PANKA, DJ. Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma. Clin Cancer Res. 2006, 12, 2371s-2375s
• KIM, HJ. NF-κB and IKK as therapeutic targeted in cancer. Cell Death Differ. 2006, 13, 738-747
• FOSTER, DA. Targeting mTOR-mediated survival signals in anticancer therapeutic strategies. Expert Rev Anticancer Ther. 2004, 4, 691-701

Terms in the title (6)： ミトコンドリア ,  DNA修復 ,  阻害 ,  扁平上皮癌 ,  アポトーシス ,  促進