Art

J-GLOBAL ID：200902277955117127   Reference number：08A0485766

Rhodium-catalyzed Reformatsky-type reaction for asymmetric synthesis of difluoro-β-lactams using menthyl group as a chiral auxiliary

ジフルオロ-6-ラクタムを不斉合成するためのキラル補助基としてメンチル基を使い,ロジウム触媒を用いたReformatskyタイプ反応

Author (9)： TARUI Atsushi (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  OZAKI Daiki (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  NAKAJIMA Naoko (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  YOKOTA Yuto (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  SOKEIRIK Yasser S. (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  SATO Kazuyuki (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  OMOTE Masaaki (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  KUMADAKI Itsumaro (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN) ,  ANDO Akira (Fac. of Pharmaceutical Sciences, Setsunan Univ., 45-1, Nagaotoge-cho, Hirakata, Osaka 573-0101, JPN)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 49  Issue： 24  Page： 3839-3843  Publication year： Jun. 09, 2008 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *lactam ,  asymmetric synthesis ,  organofluorine compound ,  *Reformatskii reaction ,  catalytic reaction ,  rhodium catalyst ,  rhodium complex ,  ester interchange ,  carboxylate(ester) ,  azomethine ,  cyclization reaction ,  absolute configuration ,  alicyclic alcohol ,  monocyclic monoterpene
Semi thesaurus term： *beta-Lactams ,  chiral auxiliary

JST classification (1)： Four-membered heterocyclic compounds  (CF07060C)

Substance index (20)： l-Menthol ,  Diethyl zinc ,  (1R,3R,4S)-3-(Bromodifluoroacetoxy)-p-menthane ,  (1S,3S,4R)-3-(Bromodifluoroacetoxy)-p-menthane ,  (1R,3S,4R)-3-(Bromodifluoroacetoxy)-p-menthane ,  N-Benzylidene-4-methoxybenzylamine ,  (4S)-1-(4-Methoxybenzyl)-3,3-difluoro-4-phenyl-2-azetidinone ,  N-(4-Methoxybenzyl)naphthalene-1-methaneimine ,  N-(4-Methoxybenzylidene)-4-methoxybenzylamine ,  N-(4-Chlorobenzylidene)-4-methoxybenzylamine ,  4-(4-Methoxybenzyliminomethyl)benzoic acid methyl ester ,  N-(4-Methoxybenzyl)cyclohexanemethaneimine ,  N-(4-Methoxybenzyl)propane-2-imine ,  (4S)-1-(4-Methoxybenzyl)-3,3-difluoro-4α-(1-naphthyl)azetidine-2-one ,  (4S)-1-(4-Methoxybenzyl)-3,3-difluoro-4α-(4-methoxyphenyl)azetidine-2-one ,  (4S)-1-(4-Methoxybenzyl)-3,3-difluoro-4α-(4-chlorophenyl)azetidine-2-one ,  4-[(2S)-1-(4-Methoxybenzyl)-3,3-difluoro-4-oxoazetidine-2β-yl]benzoic acid methyl ester ,  (4S)-1-(4-Methoxybenzyl)-3,3-difluoro-4α-cyclohexylazetidine-2-one ,  (4S)-1-(4-Methoxybenzyl)-3,3-difluoro-4α-isopropylazetidine-2-one ,  3,3-Difluoro-4α-phenylazetidine-2-one

Terms in the title (6)： ラクタム ,  不斉合成 ,  キラル補助基 ,  チル ,  ロジウム触媒 ,  タイプ