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J-GLOBAL ID：200902280968904161   Reference number：04A0850246

Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D₃ Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

HL-60細胞分化活性を有する,2-epi-ED-71を含む2α-(ω-ヒドロキシアルコキシ)-1α,25-ジヒドロキシビタミンD₃類似体およびそれらの20-エピマの設計と効率的合成

Author (9)： SAITO N (Teikyo Univ., Kanagawa, JPN) ,  SUHARA Y (Teikyo Univ., Kanagawa, JPN) ,  KURIHARA M (National Inst. Health Sci., Tokyo, JPN) ,  FUJISHIMA T (Teikyo Univ., Kanagawa, JPN) ,  HONZAWA S (Teikyo Univ., Kanagawa, JPN) ,  KOZONO T (Chugai Pharmaceutical Co., Ltd., Shizuoka, JPN) ,  MATSUMOTO M (Chugai Pharmaceutical Co., Ltd., Shizuoka, JPN) ,  OHMORI M (Chugai Pharmaceutical Co., Ltd., Shizuoka, JPN) ,  MIYATA N (National Inst. Health Sci., Tokyo, JPN)
Material： Journal of Organic Chemistry  (J Org Chem)
Volume： 69  Issue： 22  Page： 7463-7471  Publication year： Oct. 29, 2004 
JST Material Number： C0328A  ISSN： 0022-3263  CODEN： JOCEAH  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： molecular design ,...

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JST classification (3)： Steroids  (CF10040O) ,  Vitamin D  (EB07050H) ,  Cell physiology in general  (EF02010S)

Substance index (17)： Calcitriol ,  Glucose ,  Vitamin D2 ,  2α-(2-Hydroxyethoxy)-1α,25-dihydroxyvitamin D₃ ,  2-epi-ED-71 ,  1α,25-Dihydroxy-2α-(4-hydroxybutoxy)cholecalciferol ,  Methyl 3-O-[2-(tert-butyldimethylsilyloxy)ethyl]-4-O-benzoyl-6-bromo-6-deoxy-α-D-altropyranoside ,  Methyl 3-O-[3-(tert-butyldimethylsilyloxy)propyl]-4-O-benzoyl-6-bromo-6-deoxy-α-D-altropyranoside ,  Methyl 3-O-[4-(tert-butyldimethylsilyloxy)butyl]-4-O-benzoyl-6-bromo-6-deoxy-α-D-altropyranoside ,  (3R,4S,5R)-3,5-Bis(tert-butyldimethylsilyloxy)-4-[2-(tert-butyldimethylsilyloxy)ethoxy]-1-octene-7-yne ,  (3R,4S,5R)-3,5-Bis(tert-butyldimethylsiloxy)-4-[3-(tert-butyldimethylsiloxy)propoxy]-1-octene-7-yne ,  (3R,4S,5R)-3,5-Bis(tert-butyldimethylsilyloxy)-4-[4-(tert-butyldimethylsilyloxy)butoxy]-1-octene-7-yne ,  (R)-2-Methyl-6-[4-(bromomethylene)-7aβ-methylhydrindane-1β-yl]-2-heptanol ,  (S)-2-Methyl-6-[4-(bromomethylene)-7aβ-methylhydrindane-1β-yl]heptane-2-ol ,  (20S)-1α,25-Dihydroxy-2α-(2-hydroxyethoxy)cholecalciferol ,  (20S)-1α,25-Dihydroxy-2α-(3-hydroxypropoxy)cholecalciferol ,  (20S)-1α,25-Dihydroxy-2α-(4-hydroxybutoxy)cholecalciferol

Terms in the title (9)： HL-60細胞 ,  分化 ,  活性 ,  EPI ,  ED-71 ,  ジヒドロキシビタミンD3 ,  類似体 ,  エピマ ,  設計