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J-GLOBAL ID：200902281771419802   Reference number：03A0564572

Total synthesis of nafuredin-γ, a γ-lactone related to nafuredin with selective inhibitory activity against NADH-fumarate reductase.

NADH-フマル酸レダクターゼに対して選択的な阻害作用を持つナフレジンと関連するγ-ラクトン,ナフレジン-γ,の全合成

Author (9)： NAGAMITSU T (Kitasato Univ., Tokyo, JPN) ,  TAKANO D (Kitasato Univ., Tokyo, JPN) ,  SHIOMI K (Kitasato Univ., Tokyo, JPN) ,  UI H (Kitasato Univ., Tokyo, JPN) ,  YAMAGUCHI Y (Kitasato Univ., Tokyo, JPN) ,  MASUMA R (Kitasato Univ., Tokyo, JPN) ,  HARIGAYA Y (Kitasato Univ., Tokyo, JPN) ,  KUWAJIMA I (JST, Tokyo, JPN) ,  OMURA S (Kitasato Univ., Tokyo, JPN)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 44  Issue： 34  Page： 6441-6444  Publication year： Aug. 18, 2003 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： total synthesis ,...
Semi thesaurus term： *NADH oxidoreductase ,...

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JST classification (2)： Other natural substances of biological origin  (CF10090R) ,  Furans  (CF07072V)

Substance index (20)： Nafuredin ,  Nafuredin-γ ,  (5S)-3-Hydroxy-5-methyl-5-[(1R,2E)-1-hydroxy-3-(tributylstannyl)-2-propenyl]-2,5-dihydrofuran-2-one ,  (1E,3R,5E,7E,9S)-1-Iodo-3,5,9-trimethyl-1,5,7-undecatriene ,  (2R,3R)-2-Hydroxy-2-methyl-3-(tert-butyldimethylsiloxy)-4-pentynal ,  Dimethoxyphosphinyl(tert-butyldimethylsiloxy)acetic acid methyl ester ,  1-O-(4-Methoxybenzoyl)-2-methyl-L-glycerol ,  (2S)-2α-(4-Methoxybenzoyloxymethyl)-2-methyl-1,4-dioxaspiro[4.4]nonane ,  (2R)-2-Methyl-1,4-dioxaspiro[4.4]nonane-2α-methanol ,  (αE,2R)-2-Methyl-1,4-dioxaspiro[4.4]nonane-2α-acrylic acid methyl ester ,  (E)-3-[(2R)-2-Methyl-1,4-dioxaspiro[4.4]nonane-2α-yl]-2-propene-1-ol ,  (2S)-2α-[(2S)-2-Methyl-1,4-dioxaspiro[4.4]nonane-2α-yl]-3β-(chloromethyl)oxirane ,  (R)-1-[(2S)-2-Methyl-1,4-dioxaspiro[4.4]nonane-2α-yl]-2-propyne-1-ol ,  (1R)-1-O-(tert-Butyldimethylsilyl)-1-ethynyl-2-methyl-L-glycerol ,  (5S)-3-Hydroxy-5-methyl-5-[(R)-1-(tert-butyldimethylsiloxy)-2-propynyl]-2,5-dihydrofuran-2-one ,  (5S)-3-Hydroxy-5-methyl-5-[(R)-1-hydroxy-2-propynyl]-2,5-dihydrofuran-2-one ,  (5S)-3-Hydroxy-5-methyl-5-[(1R,2E)-1-(tert-butyldimethylsiloxy)-3-(tributylstannyl)-2-propenyl]-2,5-dihydrofuran-2-one ,  (5S)-3-(tert-Butyldimethylsiloxy)-5-methyl-5-[(R)-1-(tert-butyldimethylsiloxy)-2-propynyl]-2,5-dihydrofuran-2-one ,  (5S)-3-(tert-Butyldimethylsiloxy)-5-methyl-5-[(R)-1-(tert-butyldimethylsiloxy)-3-bromo-2-propynyl]-2,5-dihydrofuran-2-one ,  (5S)-3-Hydroxy-5-methyl-5-[(R)-1-(tert-butyldimethylsiloxy)-3-bromo-2-propynyl]-2,5-dihydrofuran-2-one

Terms in the title (7)： NADH ,  フマル酸レダクターゼ ,  阻害作用 ,  ナフレジン ,  ラクトン ,  ナフレジン-γ ,  全合成