Art

J-GLOBAL ID：200902285063595973   Reference number：09A0035738

Expression, Purification and Structural Analysis of Human IL-18 Binding Protein: A Potent Therapeutic Molecule for Allergy

ヒトIL-18結合蛋白質の発現,精製,構造解析: アレルギーのための強力な治療分子

Author (13)： KIMURA Takeshi (Dep. of Pediatrics, Graduate School of Medicine, Gifu Univ.) ,  KIMURA Takeshi (Dep. of Molecular Engineering, Graduate School of Engineering, Kyoto Univ.) ,  KATO Zenichiro (Dep. of Pediatrics, Graduate School of Medicine, Gifu Univ.) ,  KATO Zenichiro (Center for Emerging Infectious Diseases (CEID), Gifu Univ.) ,  KATO Zenichiro (Center for Advanced Drug Res. (CADR), Gifu Univ.) ,  OHNISHI Hidenori (Dep. of Pediatrics, Graduate School of Medicine, Gifu Univ.) ,  TOCHIO Hidehito (Dep. of Molecular Engineering, Graduate School of Engineering, Kyoto Univ.) ,  TOCHIO Hidehito (CREST, Japan Sci. and Technol. Agency) ,  SHIRAKAWA Masahiro (Dep. of Molecular Engineering, Graduate School of Engineering, Kyoto Univ.) ,  SHIRAKAWA Masahiro (CREST, Japan Sci. and Technol. Agency) ,  KONDO Naomi (Dep. of Pediatrics, Graduate School of Medicine, Gifu Univ.) ,  KONDO Naomi (Center for Emerging Infectious Diseases (CEID), Gifu Univ.) ,  KONDO Naomi (Center for Advanced Drug Res. (CADR), Gifu Univ.)
Material： Allergology International  (Allergol Int)
Volume： 57  Issue： 4  Page： 367-376 (J-STAGE)  Publication year： 2008 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *interleukin ,...
Semi thesaurus term： Receptor Activity-modifying Protein ,...

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JST classification (2)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Production and application of antigens,antibodies,complements  (ED04030W)

Reference (40)：

• OKAMURA, H. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995, 378, 88-91
• NAKANISHI, K. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 2001, 12, 53-72
• KATO, Z. The structure and binding mode of interleukin-18. Nat Struct Biol. 2003, 10, 966-971
• KATO, Z. New methods for clinical proteomics in allergy. Allergol Int. 2005, 54, 351-357
• KOJIMA, H. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells. Biochem Biophys Res Commun. 1998, 244, 183-186

Terms in the title (9)： ヒト ,  IL-18 ,  結合蛋白質 ,  発現 ,  精製 ,  構造解析 ,  アレルギー ,  治療 ,  分子