Art

J-GLOBAL ID：200902286580930185   Reference number：07A0562770

OCTN2VT, a splice variant of OCTN2, does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino acids in the first extracellular loop of OCTN2

OCTN2のスプライス変異体OCTN2VTは,OCTN2の始発細胞外ループにおける24アミノ酸の挿入により生じる小胞体の保持ゆえにカルニチンを輸送しない

Author (8)： MAEKAWA Satoshi (Dep. of Pharmacology, Hokkaido Univ. Graduate School of Medicine, Sapporo 060-8638, JPN) ,  MORI Daisuke (Dep. of Pharmacology, Hokkaido Univ. Graduate School of Medicine, Sapporo 060-8638, JPN) ,  NISHIYA Tadashi (Dep. of Pharmacology, Hokkaido Univ. Graduate School of Medicine, Sapporo 060-8638, JPN) ,  TAKIKAWA Osamu (Lab. of Radiation Safety, National Inst. for Longevity Sciences, National Center for Geriatrics and Gerontology ...) ,  HORINOUCHI Takahiro (Dep. of Pharmacology, Hokkaido Univ. Graduate School of Medicine, Sapporo 060-8638, JPN) ,  NISHIMOTO Arata (Dep. of Pharmacology, Hokkaido Univ. Graduate School of Medicine, Sapporo 060-8638, JPN) ,  KAJITA Emi (Dep. of Pharmacology, Hokkaido Univ. Graduate School of Medicine, Sapporo 060-8638, JPN) ,  MIWA Soichi (Dep. of Pharmacology, Hokkaido Univ. Graduate School of Medicine, Sapporo 060-8638, JPN)
Material： Biochimica et Biophysica Acta  (BBA. Biomembranes)
Volume： 1773  Issue： 6  Page： 1000-1006  Publication year： Jun. 2007 
JST Material Number： B0207A  ISSN： 0005-2728  CODEN： BBBMBS  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *ion pump (organism) ,...
Semi thesaurus term： splice variant ,...

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JST classification (2)： Transport of cell membrane  (EF04020R) ,  Animal biochemistry  (EJ01050P)

Substance index (1)： Carnitine

Terms in the title (7)： OCTN2 ,  スプライス変異体 ,  ループ ,  アミノ酸 ,  小胞体 ,  カルニチン ,  輸送