Art

J-GLOBAL ID：200902287791079461   Reference number：05A0337081

Site-Directed Mutagenesis Study of the Antibody 2D7 which Catalyzes a Reaction for Insertion of Cu²⁺ into Mesoporphyrin

メソポルフィリンへのCu²⁺の挿入のための反応を触媒する抗体2D7の部位特異的突然変異誘発に関する研究

Author (5)： HOSOMI Naoki (Kitasato Univ., Kanagawa, JPN) ,  KAWAMURA-KONISHI Yasuko (Kitasato Univ., Kanagawa, JPN) ,  KAWANO Ryota (Kitasato Univ., Kanagawa, JPN) ,  FUJII Ikuo (Osaka Prefecture Univ., Osaka, JPN) ,  SUZUKI Haruo (Kitasato Univ., Kanagawa, JPN)
Material： Journal of Bioscience and Bioengineering  (J Biosci Bioeng)
Volume： 99  Issue： 3  Page： 222-229  Publication year： Mar. 25, 2005 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *monoclonal antibody ,...
Semi thesaurus term： bridged compound ,...

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JST classification (1)： Production and application of antigens,antibodies,complements  (ED04030W)

Substance index (2)： Mesoporphyrin ,  Porphyrin

Reference (18)：

• 1. Tramontano, A., Janda, K. D., and Lerner, R. A.: Catalytic antibodies. Science, 234, 1566–1570 (1986).
• 2. Pollack, S. J., Jacobs, J. W., and Schultz, P. G.: Selective chemical catalysis by an antibody. Science, 234, 1570–1573 (1986).
• 3. Suzuki, H.: Recent advances in abzyme studies. J. Biochem., 115, 623–628 (1994).
• 4. Lerner, R. A., Benkovic, S. J., and Schultz, P. G.: At the crossroads of chemistry and immunology: catalytic antibodies. Science, 252, 659–667 (1991).
• 5. Kawamura-Konishi, Y., Hosomi, N., Neya, S., Sugano, S., Funasaki, N., and Suzuki, H.: Kinetic characterization of antibody-catalyzed insertion of a metal ion into porphyrin. J. Biochem., 119, 857–862 (1996).

Terms in the title (5)： メソポルフィリン ,  触媒 ,  抗体 ,  部位特異的突然変異誘発 ,  研究