Significant increase of colonic mutated crypts correlates with age in sporadic cancer and diverticulosis cases, with higher frequency in the left- than right-side colorectum

OKAYASU Isao; HANA Kiyomi; TSURUTA Tomoko; OKAMURA Nobuyoshi; OGAWA Taishi; TOKUYAMA Wataru; KAJITA Sabine; YOSHIDA Tsutomu; MIKAMI Tetuo

Art

J-GLOBAL ID：200902287816287625 Reference number：06A0356252

Significant increase of colonic mutated crypts correlates with age in sporadic cancer and diverticulosis cases, with higher frequency in the left- than right-side colorectum

散発癌および憩室症例において右側結腸直腸より左側でより高頻度に見られる結腸変異性陰かの加齢に伴う有意な増加

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Material：
Volume： 97 Issue： 5 Page： 362-367 Publication year： May. 2006
JST Material Number： W1423A ISSN： 1347-9032 Document type： Article
Article type：原著論文 Country of issue： Australia (AUS) Language： ENGLISH (EN)

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Tumors(=neoplasms)of digestive system , Chemistry,biochemistry and pathology of tumors(=neoplasms)

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ISSA, JP. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nature Genet. 1994, 7, 536-540
VOGELSTEIN, B. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988, 319, 525-532
LIPKIN, M. Biomarkers of increased susceptibility to gastrointestinal cancer. Their development and application to studies of cancer prevention. Gastroenterology. 1987, 92, 1083-1086

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