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J-GLOBAL ID：200902292169416098   Reference number：08A0029826

Apoptosis Induction Preceded by Mitochondrial Depolarization in Multiple Myeloma Cell Line U266 by 2-Aminophenoxazine-3-one

多発性骨髄腫細胞系U266において2-アミノフェノキサジン-3-オンによるミトコンドリア脱分極に先立つアポトーシス誘導

Author (8)： SHIRATO Ken (Lab. of Physiological Sciences, Fac. of Human Sciences, Waseda Univ.) ,  IMAIZUMI Kazuhiko (Lab. of Physiological Sciences, Fac. of Human Sciences, Waseda Univ.) ,  MIYAZAWA Keisuke (First Dep. of Internal Medicine, Tokyo Medical Univ.) ,  TAKASAKI Akira (Dep. of Geriatric Medicine, Tokyo Medical Univ.) ,  MIZUGUCHI Junichiro (Dep. of Immunology, Graduate School of Medicine, Kagoshima Univ.) ,  CHE Xiao-fang (Dep. of Molecular Oncology, Graduate School of Medicine, Kagoshima Univ.) ,  AKIYAMA Shinichi (Dep. of Molecular Oncology, Graduate School of Medicine, Kagoshima Univ.) ,  TOMODA Akio (Dep. of Biochemistry and Intractable, Tokyo Medical Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 31  Issue： 1  Page： 62-67 (J-STAGE)  Publication year： 2008 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： depolarization (physiology) ,...
Semi thesaurus term： DNA fragmentation ,...

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JST classification (3)： Other 6-membered rings with two hetero atoms  (CF07106V) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (2)： z-VAD-fmk ,  Questiomycin A

Reference (29)：

• HIDESHIMA, T. Nat. Rev. Cancer. 2002, 2, 927-937
• IIDA, S. Int. J. Hematol. 2003, 77, 207-212
• ANZAI, K. J. Antibiot. A. 1960, 13, 1225-1232
• SHIMIZU, S. Tohoku J. Exp. Med. 2004, 203, 47-52
• SHIMIZU, S. Oncol. Rep. 2005, 14, 41-46

Terms in the title (4)： 多発性骨髄腫 ,  細胞系 ,  ミトコンドリア脱分極 ,  アポトーシス誘導