Art

J-GLOBAL ID：200902293438226639   Reference number：08A0226542

T-type Ca²⁺ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca²⁺ channel blockers

T型Ca²⁺チャンネル遮断薬は,L型Ca²⁺チャンネル遮断薬と同様に,カルシニューリン-NFAT3活性化阻害により心臓細胞肥大を防止する

Author (12)： HORIBA Mitsuru (Dep. of Cardiovascular Res., Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  HORIBA Mitsuru (Dep. of Bioinformation Analysis, Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  MUTO Takao (Dep. of Bioinformation Analysis, Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  UEDA Norihiro (Dep. of Cardiovascular Res., Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  UEDA Norihiro (Dep. of Bioinformation Analysis, Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  OPTHOF Tobias (Dep. of Medical Physiology, Univ. Medical Center Utrecht, Utrecht, NLD) ,  MIWA Keiko (Dep. of Cardiovascular Res., Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  HOJO Mayumi (Dep. of Cardiovascular Res., Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  LEE Jong-kook (Dep. of Cardiovascular Res., Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  KAMIYA Kaichiro (Dep. of Cardiovascular Res., Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  KODAMA Itsuo (Dep. of Cardiovascular Res., Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN) ,  YASUI Kenji (Dep. of Bioinformation Analysis, Res. Inst. of Environmental Medicine, Nagoya Univ., Nagoya, JPN)
Material： Life Sciences  (Life Sciences including Pharmacology Letters)
Volume： 82  Issue： 11-12  Page： 554-560  Publication year： Mar. 12, 2008 
JST Material Number： B0699B  ISSN： 0024-3205  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Calcium Channels ,  Cardiac Myocyte ,  Mus musculus ,  Cell Proliferation ,  *cardiac hypertrophy ,  transcription factor ,  calcineurin ,  *calcium antagonist ,  *circulatory drug ,  aliphatic alcohol ,  nitrogen heterocyclic compound ,  aromatic nitro compound ,  carboxylate (ester) ,  dicarboxylic acid ,  *Calcium Channels, T-Type ,  Cell Enlargement ,  nuclear factor of activated T cells ,  *Ion Transport ,  *transportation ,  *Biological Transport ,  *transmembrane protein ,  *ion transport(in vivo) ,  Myomorpha ,  *vasodilator ,  *vasoactive drug
Semi thesaurus term： NFAT ,  クルトキシン

JST classification (1)： Basic research of cardioactive drugs  (GW07020N)

Substance index (2)： Efonidipine ,  Nisoldipine

Terms in the title (8)： T型Ca2+チャンネル ,  遮断薬 ,  L型Ca2+チャンネル ,  カルシニューリン ,  活性化 ,  阻害 ,  心臓細胞 ,  肥大