Art

J-GLOBAL ID：200902299309041167   Reference number：09A0155287

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

PH Domain-Only蛋白質PHLDA3はAktのp53調節抑制因子である

Author (17)： KAWASE Tatsuya (Radiobiology Div., National Cancer Center Res. Inst., Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JPN) ,  KAWASE Tatsuya (Dep. of Biological Sci. and Technol., Fac. of Industrial Sci. and Technol., Tokyo Univ. of Sci., Yamazaki 2641 ...) ,  KAWASE Tatsuya (SORST/JST, Kawaguchi Center Building, 4-1-8 Honcho, Kawaguchi-shi, Saitama 332-0012, JPN) ,  OHKI Rieko (Radiobiology Div., National Cancer Center Res. Inst., Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JPN) ,  OHKI Rieko (SORST/JST, Kawaguchi Center Building, 4-1-8 Honcho, Kawaguchi-shi, Saitama 332-0012, JPN) ,  SHIBATA Tatsuhiro (Cancer Genomics Project, National Cancer Center Res. Inst., Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JPN) ,  SHIBATA Tatsuhiro (Pathology Div., National Cancer Center Res. Inst., Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JPN) ,  TSUTSUMI Shuichi (Genome Sci. Div., Res. Center for Advanced Sci. and Technol., Univ. of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo ...) ,  KAMIMURA Naoko (Genome Sci. Div., Res. Center for Advanced Sci. and Technol., Univ. of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo ...) ,  INAZAWA Johji (Dep. of Molecular Cytogenetics, Medical Res. Inst., Tokyo Medical and Dental Univ., 1-5-45 Yushima, Bunkyo-ku, Tokyo ...) ,  OHTA Tsutomu (Center for Medical Genomics, National Cancer Center Res. Inst., Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JPN) ,  ICHIKAWA Hitoshi (Cancer Transcriptome Project, National Cancer Center Res. Inst., Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JPN) ,  ABURATANI Hiroyuki (Genome Sci. Div., Res. Center for Advanced Sci. and Technol., Univ. of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo ...) ,  TASHIRO Fumio (Dep. of Biological Sci. and Technol., Fac. of Industrial Sci. and Technol., Tokyo Univ. of Sci., Yamazaki 2641 ...) ,  TAYA Yoichi (Radiobiology Div., National Cancer Center Res. Inst., Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JPN) ,  TAYA Yoichi (SORST/JST, Kawaguchi Center Building, 4-1-8 Honcho, Kawaguchi-shi, Saitama 332-0012, JPN) ,  TAYA Yoichi (Cancer Res. Center of Excellence, Center for Life Sciences, #02-07, 28 Medical Drive, National Univ. of Singapore ...)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 136  Issue： 3  Page： 535-550  Publication year： Feb. 06, 2009 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *p53 protein ,  *nuclear protein ,  *serine-threonine kinase ,  Apoptosis ,  Cell Proliferation ,  Northern blotting ,  gamma-ray irradiation ,  immunoprecipitation ,  tumor cell ,  cultured cell ,  Western blotting ,  MCF7 cell ,  gene expression ,  phosphorylation ,  enzyme inhibitor ,  HEK293 cell ,  COS cell ,  phosphatidylinositol ,  subcellular distribution ,  Phosphatidylinositol bisphosphate ,  3T3 cell ,  Cell Membrane ,  Down-Regulation ,  lung tumor ,  RT-PCR ,  nitrogen heterocyclic compound ,  organofluorine compound ,  urea compound ,  hydroxy compound ,  lactam ,  COS-7 cell ,  HCT 116 cell ,  NIH 3T3 Cells ,  Phosphatidylinositol Phosphates ,  Chromatin Immunoprecipitation ,  phosphatidylinositol 4,5-bisphosphate ,  qRT-PCR ,  bioassay ,  immunoassay ,  molecular genetic phenomenon ,  Endomembrane system ,  central nervous system stimulant
Semi thesaurus term： *Akt ,  ATM ,  MM468細胞 ,  *PHLDA3 ,  Chromatin Immunoprecipitation ,  Phosphatidylinositol 4,5-Diphosphate ,  定量的RT-PCR法 ,  ホスファチジルイノシトール3,4,5-トリスりん酸

JST classification (2)： Biological function  (EB03040U) ,  Gene expression  (EC02040Q)

Substance index (4)： Fluorouracil ,  LY-294002 ,  z-VAD-fmk ,  Caffeine

Terms in the title (6)： pH ,  蛋白質 ,  Akt ,  p53 ,  調節 ,  抑制因子