Art

J-GLOBAL ID：200902299333246799   Reference number：09A1053084

Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice

海洋カロチノイド,フコキサンチン(FX)のマウスにおける単回と連続投与毒性試験

Author (5)： BEPPU Fumiaki (Res. Center for Functional Food Materials, Sunny Health Holdings Co., Ltd.) ,  NIWANO Yoshimi (Res. Center for Functional Food Materials, Sunny Health Holdings Co., Ltd.) ,  TSUKUI Takayuki (Fac. of Fisheries, Hokkaido Univ.) ,  HOSOKAWA Masashi (Fac. of Fisheries, Hokkaido Univ.) ,  MIYASHITA Kazuo (Fac. of Fisheries, Hokkaido Univ.)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 34  Issue： 5  Page： 501-510 (J-STAGE)  Publication year： 2009 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *carotenoid ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=09A1053084&from=J-GLOBAL&jstjournalNo=Z0265B") }}

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (2)： Fucoxanthin ,  Fucoxanthinol

Reference (29)：

• ASAI, A. Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells : formation and cytotoxicity of fucoxanthin metabolites. Drug. Metab. Dispos. 2004, 32, 205-211
• DAS, S. K. Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D. Biochim. Biophys. Acta. 2008, 1780, 743-749
• FISCHER, R. Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension. Hypertension. 2008, 51, 540-546
• GARBER, C. C. Jendrassik-Grof analysis for total and direct bilirubin in serum with a centrifugal analyzer. Clin. Chem. 1981, 27, 1410-1416
• HARRIS, W. S. Omega-3 fatty acids and coronary heart disease risk : clinical and mechanistic perspectives. Atherosclerosis. 2008, 197, 12-24

Terms in the title (6)： 海洋 ,  カロチノイド ,  フコキサンチン ,  マウス ,  連続投与 ,  毒性試験