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J-GLOBAL ID：200902299905385213   Reference number：09A0089753

PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression

ヒトPPM1Dの新規選択的スプライシング変異体PPM1D430はp53を脱リン酸し,特異的組織発現を示す

Author (6)： CHUMAN Yoshiro (Hokkaido Univ., Sapporo, JPN) ,  KURIHASHI Wataru (Hokkaido Univ., Sapporo, JPN) ,  MIZUKAMI Yohei (Hokkaido Univ., Sapporo, JPN) ,  NASHIMOTO Takehiro (Hokkaido Univ., Sapporo, JPN) ,  YAGI Hiroaki (Hokkaido Univ., Sapporo, JPN) ,  SAKAGUCHI Kazuyasu (Hokkaido Univ., Sapporo, JPN)
Material： Journal of Biochemistry  (JB)
Volume： 145  Issue： 1  Page： 1-12  Publication year： Jan. 01, 2009 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *PPM1D430

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JST classification (2)： Enzyme in general  (EB09010D) ,  Animal biochemistry  (EJ01050P)

Reference (50)：

• FISCELLA, M. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc. Natl Acad. Sci. USA. 1997, 94, 6048-6053
• TAKEKAWA, M. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J. 2000, 19, 6517-6526
• LU, X. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev. 2005, 19, 1162-1174
• FUJIMOTO, H. Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death Differ. 2006, 13, 1170-1180
• OLIVA-TRASTOY, M. The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. Oncogene. 2007, 26, 1449-1458

Terms in the title (7)： ヒト ,  PPM1D ,  選択的スプライシング ,  変異体 ,  p53 ,  脱リン ,  組織発現