Art

J-GLOBAL ID：200902299905385213   Reference number：09A0089753

PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression

ヒトPPM1Dの新規選択的スプライシング変異体PPM1D430はp53を脱リン酸し,特異的組織発現を示す

Author (6)： CHUMAN Yoshiro (Hokkaido Univ., Sapporo, JPN) ,  KURIHASHI Wataru (Hokkaido Univ., Sapporo, JPN) ,  MIZUKAMI Yohei (Hokkaido Univ., Sapporo, JPN) ,  NASHIMOTO Takehiro (Hokkaido Univ., Sapporo, JPN) ,  YAGI Hiroaki (Hokkaido Univ., Sapporo, JPN) ,  SAKAGUCHI Kazuyasu (Hokkaido Univ., Sapporo, JPN)
Material： Journal of Biochemistry  (JB)
Volume： 145  Issue： 1  Page： 1-12  Publication year： Jan. 01, 2009 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： immunological reaction ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=09A0089753&from=J-GLOBAL&jstjournalNo=W1920A") }}

JST classification (2)： Enzyme in general  (EB09010D) ,  Animal biochemistry  (EJ01050P)

Reference (50)：

• FISCELLA, M. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc. Natl Acad. Sci. USA. 1997, 94, 6048-6053
• TAKEKAWA, M. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J. 2000, 19, 6517-6526
• LU, X. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev. 2005, 19, 1162-1174
• FUJIMOTO, H. Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death Differ. 2006, 13, 1170-1180
• OLIVA-TRASTOY, M. The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. Oncogene. 2007, 26, 1449-1458

Terms in the title (7)： ヒト ,  PPM1D ,  選択的スプライシング ,  変異体 ,  p53 ,  脱リン ,  組織発現