Suzuki Mikiko

スズキミキコ | Suzuki Mikiko

Affiliation and department：
Job title： Lecturer

Research field (2)： Medical biochemistry , Tumor biology

Research theme for competitive and other funds (9)：

2020 - 2023 EVI1-GATA2バランスによる3q白血病悪性化機構の解析
2018 - 2020 Conditions for the proto-oncogene EVI1 to induce leukemia
2015 - 2019 Mechanisms of leukemogenesis by the leukemia-driving enhancer
2014 - 2018 Role of DNA Methyltransferase 1 in the Epigenetic Regulation of Beta-type Globin Genes
2014 - 2017 Development of novel therapeutic strategies for sickle cell disease by activating Nrf2

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Papers (48)：

Shimizu R, Hirano I, Hasegawa A, Suzuki M, Otsuki A, Taguchi K, Katsuoka F, Uruno A, Suzuki N, Yumoto A, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Commun Biol. 2023. 6
Wataru Hirose, Makoto Horiuchi, Donghan Li, Ikuko N Motoike, Lin Zhang, Hafumi Nishi, Yusuke Taniyama, Takashi Kamei, Mikiko Suzuki, Kengo Kinoshita, et al. Selective Elimination of NRF2-Activated Cells by Competition with Neighboring Cells in the Esophageal Epithelium. Cellular and molecular gastroenterology and hepatology. 2022. 15. 1. 153-178
Ayumi Kuga, Kouhei Tsuchida, Harit Panda, Makoto Horiuchi, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Mikiko Suzuki, Masayuki Yamamoto. The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo. Molecular and cellular biology. 2022. 42. 7. e0056321
Harit Panda, Mikiko Suzuki, Mitsuru Naito, Ritsumi Saito, Huaichun Wen, Liam Baird, Akira Uruno, Kanjiro Miyata, Masayuki Yamamoto. Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity. Free radical biology & medicine. 2022. 187. 92-104
Harit Panda, Huaichun Wen, Mikiko Suzuki, Masayuki Yamamoto. Multifaceted Roles of the KEAP1-NRF2 System in Cancer and Inflammatory Disease Milieu. Antioxidants (Basel, Switzerland). 2022. 11. 3

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MISC (15)：

大森慎也, 鈴木未来子, 高井淳, 森口尚, 森哲哉, 大根田絹子. Identification and analysis of a distal Gata2 enhancer that is required for increasing Gata2 gene expression during mast cell and basophil maturation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
片山紗乙莉, 鈴木未来子, 笹原洋二, 呉繁夫, 山本雅之. GATA2ハプロ不全はEVI1誘導性白血病の発症を促進する. 日本小児血液・がん学会雑誌. 2019. 56. 2. 159-162
Mikiko Suzuki. Diseases associated with GATA2 gene enhancer abnormalities. Seikagaku. 2017. 89. 3. 391-399
Nadine Keleku-Lukwete, Panda Harit, Eriko Naganuma, Mikiko Suzuki, Masayuki Yamamoto. Specific Deletion of Keap1 in Endothelial Cells or/and Macrophages of SCD Mice Induces Nrf2 to Protect Tissues Against Oxidative Insults. BLOOD. 2016. 128. 22
片山紗乙莉, 鈴木未来子, 呉繁夫, 山本雅之. GATA2遺伝子ヘテロ欠失は3番染色体逆位を伴う白血病の発症を促進する. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [2T07-01(2P

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Lectures and oral presentations (20)：

GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis
(IUBMB Focused Meeting on GATA Transcription Factors 2018)
エンハンサーハイジャッキングによる白血病発症機構
(小児科イブニングカンファレンス 2017)
Chromosomal rearrangements between 3q21 and 3q26 induce leukemogenesis by misdirecting both EVI1 and GATA2 genes
(2016)
エンハンサーの破綻が引き起こす血液疾患の解析
(第89回日本生化学会大会 2016)
染色体転座を伴う白血病モデルマウスの開発とEVI1陽性白血病の解析
(第386回東北医学会例会シンポジウム 2015)

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Professional career (1)：

Awards (2)：

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