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J-GLOBAL ID：201902284453741900   Reference number：19A2634442

GATA2 haploinsufficiency accelerates EVI-1-driven leukemogenesis in an inv(3)(q21q26) mouse model

GATA2ハプロ不全はEVI1誘導性白血病の発症を促進する

Author (5)： KATAYAMA SAORI (東北大学医学部小児科) ,  SUZUKI MIKIKO (東北大学医学部医化学分野) ,  SASAHARA YOJI (東北大学医学部小児科) ,  KURE SHIGEO (東北大学医学部小児科) ,  YAMAMOTO MASAYUKI (東北大学医学部医化学分野)
Material： 日本小児血液・がん学会雑誌(Web)  (Japanese Journal of Pediatric Hematology/Oncology (Web))
Volume： 56  Issue： 2  Page： 159-162(J-STAGE)  Publication year： 2019 
JST Material Number： U0774A  ISSN： 2189-5384  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *gene ,...
Semi thesaurus term： Gata2 gene

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Author keywords (8)： GATA2 ,  EVI1 ,  3q異常 ,  白血病 ,  GATA2 ,  EVI1 ,  3q rearrangement ,  leukemia

JST classification (2)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Carcinogenic mechanisms and factors  (GE02020C)

Reference (13)：

• 1) Morishita K, Parganas E, William CL, et al: Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26. Proc Natl Acad Sci U S A 89: 3937-3941, 1992.
• 2) Suzukawa K, Parganas E, Gajjar A, et al: Identification of a breakpoint cluster region 3′ of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26). Blood 84: 2681-2688, 1994.
• 3) Groschel S, Sanders MA, Hoogenboezem R, et al: A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. Cell 157: 369-381, 2014.
• 4) Yamazaki H, Suzuki M, Otsuki A, et al: A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression. Cancer Cell 25, 415-427, 2014.
• 5) Arber DA, Orazi A, Hasserjian R, et al: The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127, 2391-2405, 2016.

Terms in the title (6)： GATA2 ,  ハプロ不全 ,  EVI1 ,  白血病 ,  発症 ,  促進