Rchr

J-GLOBAL ID：201001041287512330 Update date: Jan. 30, 2024

Demachi-Okamura Ayako

オカムラアヤコ | Demachi-Okamura Ayako

Affiliation and department：
Homepage URL (1)： https://www.pref.aichi.jp/cancer-center/ri/01bumon/08hatsugan_seigyo/03member.html

Research field (2)： Tumor diagnostics and therapeutics , Immunology

Research keywords (3)：腫瘍免疫 , 細胞傷害性Tリンパ球 , 腫瘍抗原

Research theme for competitive and other funds (6)：

2021 - 2023 免疫一細胞データ解析による改変型T細胞受容体デザイン技術の開発
2018 - 2022 Affinity maturation of cancer-specific TCRs by in vitro cell display methods and their application to drug discovery.
2019 - 2022 オートファジー亢進型膵臓がんに対するがん免疫治療ターゲットの探索
2016 - 2019 オートファジーによって生成されるエピトープによる抗腫瘍効果の検討
2013 - 2016 活性型変異Rasによって誘導されるオートファジー介在性抗原提示機構の解明

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Papers (23)：

Development of TCR-T cell therapy targeting mismatched HLA-DPB1 for relapsed leukemia after allogeneic transplantation. 2023. (in press)
Ohta R, Demachi-Okamura A, Akatsuka Y, Fujiwara H, Kuzushima K. Improving TCR affinity on 293T cells. J Immunol Methods. 2019. 466. 1-8
Kataoka K, Miyoshi H, Sakata S, Dobashi A, Couronné L, Kogure Y, Sato Y, Nishida K, Gion Y, Shiraishi Y, et al. Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas. Leukemia. 2019. 33. 7. 1687-1699
Yoko Inaguma, Yoshiki Akatsuka, Kohei Hosokawa, Hiroyuki Maruyama, Akinao Okamoto, Takamasa Katagiri, Keiko Shiraishi, Yuko Murayama, Sachiko Tsuzuki-Iba, Yuuki Mizutani, et al. Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia. BRITISH JOURNAL OF HAEMATOLOGY. 2016. 172. 1. 131-134
E. Yamada, A. Demachi-Okamura, S. Kondo, Y. Akatsuka, S. Suzuki, K. Shibata, F. Kikkawa, K. Kuzushima. Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs. TISSUE ANTIGENS. 2015. 86. 3. 164-171

ｍore...

MISC (1)：

Seiko Iwata, Kaoru Wada, Satomi Tobita, Kensei Gotoh, Yoshinori Ito, Ayako Demachi-Okamura, Norio Shimizu, Yukihiro Nishiyama, Hiroshi Kimura. Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection. JOURNAL OF GENERAL VIROLOGY. 2010. 91. 1. 42-50

Patents (1)：

日本特許(特願2005-315306)「エプス

Professional career (1)：

博士(医学)

Work history (6)：

2019/04 - 現在 Aichi Cancer Center, Research Institute
2018 - 2019 Aichi Cancer Center, Research Institute
2015 - 2018 Aichi Cancer Center, Research Institute
2009 - 2015 Aichi Cancer Center, Research Institute
2007 - 2008 Aichi Cancer Center, Research Institute

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Committee career (1)：

2016 - 2016 日本学術振興会審査委員

Awards (1)：

2009 - 第13回日本がん免疫学会総会第1回若手研究奨励賞

Association Membership(s) (3)：

JAPANESE SOCIETY FOR IMMUNOLOGY (JSI) , 日本がん免疫学会 , THE JAPANESE CANCER ASSOCIATION

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