Research field (3)：
Pharmaceuticals - chemistry and drug development
, Biophysics
, Pharmaceuticals - analytical and physicochemistry
Research keywords (4)：
相互作用解析
, 動的構造
, NMR
, 構造生物学
Research theme for competitive and other funds (22)：
2022 - 2025 in cell structure-guided drug development by NMR
2021 - 2024 Molecular basis for biosynthetic and degradation systems for tRNA sulfur-modified bases
2023 - 2024 技術集約型オープンイノベーションによるNMR細胞内創薬の実現
2020 - 2023 高活性化合物を創生し創薬標的の枯渇を解消する動的構造創薬技術の確立
2020 - 2023 GTP代謝制御によるウイルス複製阻害技術の開発
2020 - 2022 Development of basic strategy to structurally evaluate the membrane permeation activity of middle-size molecules
2020 - 2022 分子夾雑環境下におけるタンパク質と薬物の動的相互作用解析
2019 - 2022 Identification and Functional Analysis of the Target Molecule of Terrein, a Small Molecule Compound for Application in the Super-Aging Society
2018 - 2022 Analysis of functional dynamics of membrane proteins in different membrane environments
2017 - 2022 in situ functional analyses of membrane proteins by NMR
2018 - 2020 NMR method to obtain structural fingerprints of an intact monoclonal antibody acquired under formulated storage conditions
2015 - 2018 NMR approach for the functional structural analyses of human membrane proteins
2015 - 2017 Investigation of molecular mechanism of transphosphorylation by a phosphatidylinositol kinase
2015 - 2017 Structural biology of the intrinsically disordered region of CagA
2014 - 2017 汎特異的相互作用を基盤とする多剤耐性機構の動的立体構造解析
2014 - 2015 多剤耐性転写制御因子の動的薬剤認識と機能発現のNMR解析
2013 - 2015 X線結晶構造解析・核磁気共鳴法の融合によるキナーゼ複合体の動的立体構造解析
2012 - 2015 Fundamental research for NMR structural analysis of human membrane proteins
2011 - 2013 原核生物多剤耐性トランスポーターの構造揺らぎと薬剤排出活性のNMR解析
2011 - 2012 Structure determination and elucidation of transport mechanism of mitochondrial inner membrane transporter
Yuko Otani, Asami Ichinose, Xihong Wang, Zhihan Huang, Akitomo Kasahara, Mayumi Ishii, Eri Watanabe, Kayoko Kanamitsu, Kempei Tai, Hiroyuki Kusuhara, et al. An N-ortho-nitrobenzylated benzanilide amino acid enables control of the conformation and membrane permeability of cyclic peptides. Chemical communications (Cambridge, England). 2024
Koh Takeuchi, Takumi Ueda, Misaki Imai, Miwa Fujisaki, Mie Shimura, Yuji Tokunaga, Yutaka Kofuku, Ichio Shimada. Affinity-directed substrate/H+-antiport by a MATE transporter. Structure (London, England : 1993). 2024
Satoshi Kofuji, Kara Wolfe, Kazutaka Sumita, Shun Kageyama, Hirofumi Yoshino, Yoshihisa Hirota, Aki Ogawa-Iio, Hirotaka Kanoh, Mika Sasaki, Kaori Kofuji, et al. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochemical and biophysical research communications. 2024. 718. 149981-149981
Marin Yokomine, Jumpei Morimoto, Yasuhiro Fukuda, Takumi Ueda, Koh Takeuchi, Koji Umezawa, Hideo Ago, Hiroaki Matsuura, Go Ueno, Akinobu Senoo, et al. A High-Resolution Structural Characterization and Physicochemical Study of How a Peptoid Binds to an Oncoprotein MDM2. Chemical Science. 2024
宮川柊兵, 奥脇弘次, 奥脇弘次, 奥脇弘次, 古石誉之, 米持悦生, 千田美紀, 千田俊哉, 竹内恒, 福澤薫, et al. Analysis of PI5P4Kβ: Elucidation of GTP specificity by computational approach. 日本薬学会年会要旨集(Web). 2024. 144th
上田 卓見, 幸福 裕, 竹内 恒, 今井 駿輔, 白石 勇太郎, 嶋田 一夫. 溶液NMR法によるGPCRの活性と直結する動的構造平衡の解明-Function-Related Conformational Dynamics of GPCRs Revealed by Solution NMR-ミニ特集 生理学的環境での生体高分子の挙動の観察可能性の追求. 日本結晶学会誌 = Journal of the Crystallographic Society of Japan. 2022. 64. 4. 279-284
廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, 河野龍義, 中村能久, 中村能久, 竹内恒, 千田俊哉, 佐々木敦朗, et al. Metabolic regulation by the GTP sensor PI5P4Kβ: towards the treatment of diabetes, cancer cachexia and sarcopenia. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, 河野龍義, 中村能久, 中村能久, TILVE Diego, 竹内恒, 千田俊哉, et al. Metabolic dysregulation by disruption of GTP resilience: a new pathological mechanism for metabolic diseases. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
竹内恒, 池田幸樹, 千田美紀, 原田彩佳, 奥脇弘次, 福澤薫, 中川草, 長瀬里沙, 今井美咲, 廣田佳久, et al. Molecular evolution of PI5P4Kβ that underlies the GTP resilience. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
