Rchr
J-GLOBAL ID：201001095010684579   Update date: Jun. 06, 2024

Ogi Tomoo

オギ トモオ | Ogi Tomoo
Affiliation and department：
Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection

About Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection


Job title： Professor
Other affiliations (1)：
Homepage URL  (1)： http://133.6.134.122/wordpress/
Research field  (6)： Environmental effects of chemicals ,  Environmental effects of radiation ,  Medical biochemistry ,  Molecular biology ,  Dermatology ,  Pathobiochemistry
Research keywords  (13)： DNA repair; human genetics; nucleotide excision repair; genome ,  Human Genetics ,  DNA修復 ,  ヌクレオチド除去修復 ,  発がん ,  突然変異 ,  転写と共役したヌクレオチド除去修復 ,  放射線DNA損傷 ,  乳癌 ,  タンパク質間相互作用 ,  ゲノム医科学 ,  BRCA2 ,  DNA損傷修復
Research theme for competitive and other funds  (29)：
  • 2022 - 2025 薬剤耐性・変異株解析可能なリアルタイム次世代シークエンスによる重症感染症迅速診断
  • 2021 - 2024 転写共役修復 (TCR)の分子メカニズム解明とTCR欠損ヒト遺伝性疾患の分子病態
  • 2020 - 2024 MYRF遺伝子を起点とした発熱時言動異常の病態解明
  • 2020 - 2023 ロングリード配列決定法による放射線被ばく刻印の同定
  • 2020 - 2023 Molecular pathogenesis of human disorders associated with deficiencies in the DNA repair and environmental stress response systems
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Papers (115)：
  • Paula J. van der Meer, George Yakoub, Yuka Nakazawa, Tomoo Ogi, Martijn Luijsterburg. Clearance of DNA damage-arrested RNAPII is selectively impaired in Cockayne syndrome cells. 2024
  • Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada, Tomoo Ogi. Endogenous aldehyde-induced DNA-protein crosslinks are resolved by transcription-coupled repair. Nature cell biology. 2024
  • Tatsuhiro Noda, Takuya Takeichi, Kana Tanahashi, Yasushi Ogawa, So Takeuchi, Takenori Yoshikawa, Erika Toriyama, Miwa Ashida, Sumihisa Imakado, Hitoshi Tsuchihashi, et al. Updated mutational spectrum and genotype-phenotype correlations in ichthyosis patients with ABCA12 pathogenic variants. Experimental dermatology. 2024. 33. 4. e15072
  • Paniz Farshadyeganeh, Takahiro Yamada, Hirofumi Ohashi, Gen Nishimura, Hiroki Fujita, Yuriko Oishi, Misa Nunode, Shuku Ishikawa, Jun Murotsuki, Yuri Yamashita, et al. Dyssegmental dysplasia Rolland-Desbuquois type is caused by pathogenic variants in HSPG2 - a founder haplotype shared in five patients. Journal of human genetics. 2024
  • Miyu Misaki, Takuya Takeichi, Michiya Omi, Yasutoshi Ito, Tomoo Ogi, Yoshinao Muro, Masashi Akiyama. Localized epidermolysis bullosa simplex caused by a previously unreported substitution in the linker 12 domain of keratin 14. The Journal of dermatology. 2024
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MISC (8)：
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Patents (4)：
Lectures and oral presentations  (4)：
  • RNA polymerase IIのユビキチン化修飾による転写共役修復開始反応の分子機構とその破綻により発症する哺乳類の神経変性のメカニズム
    (第42回日本分子生物学会年会 2019)
  • 希少未診断疾患におけるゲノム解析およびデータ評価パイプラインの構築
    (第4回名大医薬系3部局交流シンポジウム 2019)
  • Mutations in UVSSA cause UV sensitive syndrome
    (Responses to DNA damage: from molecular mechanism to human disease 2011)
  • Mutations in UVSSA cause UV sensitive syndrome
    (2011)
Works (16)：
  • ヌクレオチド除去修復欠損性日光過敏症のウイルス発現系とゲノム解析による網羅的探索
    2012 - 2014
  • 紫外線感受性症候群責任因子によるRNAポリメラーゼユビキチン化と待避機構の解析
    2012 - 2014
  • 放射線損傷DNA修復過程における複製忠実度の 低いDNAポリメラーゼによる突然変異誘発機構の解析
    2011 - 2012
  • DNA修復過程でのヌクレオシドの取り込みを指標とした不正確な修復合成を誘発するDNA修復因子の探索
    2010 - 2011
  • ヌクレオチド除去修復過程における修復DNA合成の分子メカニズムの解明
    2010 - 2011
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Professional career (1)：
  • D. Sci. (Kyoto University)
Work history (4)：
  • 2021/01 - 現在 Nagoya University
  • 2015/04/01 - 現在 Nagoya University Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Professor
  • 2015/04 - 現在 Nagoya University Research Institute of Environmental Medicine (RIeM) Professor of Genetics
  • 2014 - 2015 Nagasaki University
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