Art

J-GLOBAL ID：201002019297366861   Reference number：80A0202394

Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.

3-ヒドロキシ-3-メチルグルタリルコエンザイムAレダクターゼを特異的に阻害する新しいコレステロール血症低下薬,モナコリンK

Author (1)： ENDO A (Tokyo Noko Univ.)
Material： J Antibiot  (Journal of Antibiotics. Series A)
Volume： 33  Issue： 3  Page： 334-336  Publication year： 1980 
JST Material Number： G0489A  ISSN： 0021-8820  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： 真菌類 ,...

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Reference (11)：

• 1) ENDO, A.: Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J. Antibiotics 32: 852-854, 1979
• 2) ENDO, A.; M. KURODA & Y. TSUJITA: ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by <i>Penicillium citrinum</i>. J. Antibiotics 29: 1346-1348,1976
• 3) ENDO, A.; M. KURODA & K. TANZAWA: Cony petitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B, fungal metabolites having hypocholesterolemic activity. FEBS Letters 72: 323-326, 1976
• 4) KURODA, M.; K. TANZAWA, Y. TSUJITA & A. ENDO: Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in Triton WR-1 339-induced hypercholesterolemia. Biochim. Biophys. Acta 489: 119-25, 1977
• 5) TSUJITA, Y.; M. KURODA, K. TANZAWA, N. KITANO & A. ENDO: Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Atherosclerosis 32: 307-313, 1979

Terms in the title (4)： レダクターゼ ,  阻害 ,  コレステロール血症 ,  モナコリンK