Art

J-GLOBAL ID：201002200858506044   Reference number：10A0019697

Synthesis of (S)-Ketamine via [1,3]-Chirality Transfer of a Stereocenter Created by Enantioselective Aldol Reaction

エナンチオ選択的アルドール反応により創造された立体中心の[1,3]キラリティー移動を経る(S)-ケタミンの合成

Author (6)： YOKOYAMA Takeshi (Dep. of Dental Anesthesiology, Fac. of Dental Sci., Kyushu Univ.) ,  YOKOYAMA Reiko (Dep. of Anesthesiology and Critical Care Medicine, Kochi Medical School) ,  NOMURA Satoshi (Dep. of Materials Sci., Fac. of Sci., Kochi Univ.) ,  MATSUMOTO Satoshi (Dep. of Materials Sci., Fac. of Sci., Kochi Univ.) ,  FUJIYAMA Ryoji (Dep. of Materials Sci., Fac. of Sci., Kochi Univ.) ,  KIYOOKA Syun-ichi (Dep. of Materials Sci., Fac. of Sci., Kochi Univ.)
Material： Bulletin of the Chemical Society of Japan  (Bull Chem Soc Jpn)
Volume： 82  Issue： 12  Page： 1528-1532 (J-STAGE)  Publication year： 2009 
JST Material Number： G0450A  ISSN： 0009-2673  CODEN： BCSJA8  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： asymmetric synthesis ,...
Semi thesaurus term： chirality ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=10A0019697&from=J-GLOBAL&jstjournalNo=G0450A") }}

JST classification (2)： Aromatic monocyclic halogen compounds  (CF05030H) ,  Synthesis of drugs  (GV01030F)

Substance index (4)： (S)-Ketamine ,  (S)-3-[2-(o-Chlorophenyl)-1-cyclohexenyl]-3-hydroxypropanoic acid phenyl ester ,  [(E)-1-(o-Chlorophenyl)-2-[3-(benzyloxy)propylidene]cyclohexane-1β-yl] isocyanate ,  (E)-N-Methyl-1-(o-chlorophenyl)-2-[3-(benzyloxy)propylidene]cyclohexane-1β-amine

Reference (33)：

• 1) a) Ketamine is included as a general anesthetic in the 14th WHO model list of essential medicines. WHO Technical Report Series 942, WHO Expert Committee on Drug Dependence: thirty-fourth report, 2006.
•  b) W. E. Childers, Jr., R. B. Baudy, J. Med. Chem. 2007, 50, 2557.
• 2) C. L. Stevens, U. S. Patent 3254124;
•  C. L. Stevens, Chem. Abstr. 1968, 65, 5414.
• 3) a) C. L. Stevens, A. Thuillier, F. A. Daniher, J. Org. Chem. 1965, 30, 2962.

Terms in the title (5)： アルドール反応 ,  創造 ,  立体中心 ,  キラリティー ,  ケタミン