Art
J-GLOBAL ID：201002210025740642   Reference number：10A1069459

Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: Enzymes and catalysis

遺伝的に改変したCYP105A1によるビタミンD3の三段階でのヒドロキシル化
Author (11)：
HAYASHI Keiko

About HAYASHI Keiko

(Toyama Prefectural Univ., Toyama, JPN)

About Toyama Prefectural Univ., Toyama, JPN

, 
YASUDA Kaori

About YASUDA Kaori

(Toyama Prefectural Univ., Toyama, JPN)

About Toyama Prefectural Univ., Toyama, JPN

, 
SUGIMOTO Hiroshi

About SUGIMOTO Hiroshi

(RIKEN, Hyogo, JPN)

About RIKEN, Hyogo, JPN

, 
IKUSHIRO Shinichi

About IKUSHIRO Shinichi

(Toyama Prefectural Univ., Toyama, JPN)

About Toyama Prefectural Univ., Toyama, JPN

, 
KAMAKURA Masaki

About KAMAKURA Masaki

(Toyama Prefectural Univ., Toyama, JPN)

About Toyama Prefectural Univ., Toyama, JPN

, 
KITTAKA Atsushi

About KITTAKA Atsushi

(Teikyo Univ., Kanagawa, JPN)

About Teikyo Univ., Kanagawa, JPN

, 
HORST Ronald L.

About HORST Ronald L.

(Heartland Assays Inc., IA, USA)

About Heartland Assays Inc., IA, USA

, 
CHEN Tai C.

About CHEN Tai C.

(Boston Univ. School of Medicine, Massachusetts, USA)

About Boston Univ. School of Medicine, Massachusetts, USA

, 
OHTA Miho

About OHTA Miho

(Soai Univ., Osaka, JPN)

About Soai Univ., Osaka, JPN

, 
SHIRO Yoshitsugu

About SHIRO Yoshitsugu

(RIKEN, Hyogo, JPN)

About RIKEN, Hyogo, JPN

, 
SAKAKI Toshiyuki

About SAKAKI Toshiyuki

(Toyama Prefectural Univ., Toyama, JPN)

About Toyama Prefectural Univ., Toyama, JPN


Material：
FEBS Journal  (FEBS J)

About FEBS Journal


Volume： 277  Issue： 19  Page： 3999-4009  Publication year： Oct. 2010 
JST Material Number： B0206B  ISSN： 1742-464X  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*cytochrome P450

About cytochrome P450

, 
enzyme

About enzyme

, 
microbiological reaction

About microbiological reaction

, 
enzyme availed reaction

About enzyme availed reaction

, 
organism

About organism

, 
metabolite

About metabolite

, 
Computer Simulation

About Computer Simulation

, 
binding site

About binding site

, 
enzyme substrate complex

About enzyme substrate complex

, 
enzyme kinetics

About enzyme kinetics

, 
sterol

About sterol

, 
secosteroid

About secosteroid

, 
alicyclic alcohol

About alicyclic alcohol

, 
polyol

About polyol

, 
vitamin D

About vitamin D

, 
polyene

About polyene

, 
diol

About diol

, 
hydroxylation

About hydroxylation

, 
*CYP105A1

About CYP105A1

, 
Streptomyces lividans

About Streptomyces lividans

, 
docking simulation

About docking simulation

, 
microbial conversion

About microbial conversion

, 
mutant enzyme

About mutant enzyme

, 
Streptomyces

About Streptomyces

, 
Genetically Modified Organism

About Genetically Modified Organism

, 
computer application

About computer application

, 
utilization

About utilization

, 
microorganism

About microorganism

, 
Actinomycetales

About Actinomycetales


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
Streptomyces

About Streptomyces

, 
hydroxylation

About hydroxylation

, 
transgenic organism

About transgenic organism


JST classification (3)：
JST classification
Category name(code) classified by JST.
Enzyme in general 
(EB09010D)

About Enzyme in general

,  Gene manipulation 
(EC02050B)

About Gene manipulation

,  Substance production by microorganisms,cultured tissues/cells in general 
(FK03010P)

About Substance production by microorganisms,cultured tissues/cells in general

Substance index (5)：
Substance index
Chemical Substance indexed to the Article.
Calcitriol

About Calcitriol

, 
Calcifediol

About Calcifediol

, 
Vitamin D3

About Vitamin D3

, 
(5Z,7E,25R)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25,26-tetraol

About (5Z,7E,25R)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25,26-tetraol

, 
(25S)-1α,25,26-Trihydroxycholecalciferol

About (25S)-1α,25,26-Trihydroxycholecalciferol

Terms in the title (6)：
Terms in the title
Keywords automatically extracted from the title.
遺伝

About 遺伝

, 
改変

About 改変

, 
CYP105A1

About CYP105A1

, 
ビタミンD3

About ビタミンD3

, 
段階

About 段階

, 
ヒドロキシル化

About ヒドロキシル化


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