Art

J-GLOBAL ID：201002215225673658   Reference number：10A0019717

Differential Coupling of Human Endothelin Type A Receptor to G_q/11 and G₁₂ Proteins: the Functional Significance of Receptor Expression Level in Generating Multiple Receptor Signaling

ヒトエンドセリンA型受容体のG_q/11とG₁₂蛋白質への異なるカップリング:複数の受容体シグナリング生成での受容体発現量の機能的意義

Author (7)： HORINOUCHI Takahiro (Dep. of Cellular Pharmacology, Hokkaido Univ. Graduate School of Medicine, JPN) ,  ASANO Hiroshi (Dep. of Cellular Pharmacology, Hokkaido Univ. Graduate School of Medicine, JPN) ,  HIGA Tunaki (Dep. of Cellular Pharmacology, Hokkaido Univ. Graduate School of Medicine, JPN) ,  NISHIMOTO Arata (Dep. of Cellular Pharmacology, Hokkaido Univ. Graduate School of Medicine, JPN) ,  NISHIYA Tadashi (Dep. of Cellular Pharmacology, Hokkaido Univ. Graduate School of Medicine, JPN) ,  MURAMATSU Ikunobu (Div. of Pharmacology, Dep. of Biochemistry and Bioinformative Sciences, School of Medicine, Univ. of Fukui, JPN) ,  MIWA Soichi (Dep. of Cellular Pharmacology, Hokkaido Univ. Graduate School of Medicine, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 111  Issue： 4  Page： 338-351 (J-STAGE)  Publication year： 2009 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...

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JST classification (1)： Receptors on cell membrane  (EF04030C)

Substance index (1)： Endothelin-1

Reference (36)：

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• 2 Miwa S, Kawanabe Y, Okamoto Y, Masaki T. Ca²⁺ entry channels involved in endothelin-1-induced contractions of vascular smooth muscle cells. J Smooth Muscle Res. 2005;41:61–75.
• 3 Enoki T, Miwa S, Sakamoto A, Minowa T, Komuro T, Kobayashi S, et al. Long-lasting activation of cation current by low concentration of endothelin-1 in mouse fibroblasts and smooth muscle cells of rabbit aorta. Br J Pharmacol. 1995;115:479–485.
• 4 Iwamuro Y, Miwa S, Minowa T, Enoki T, Zhang XF, Ishikawa M, et al. Activation of two types of Ca²⁺-permeable nonselective cation channel by endothelin-1 in A7r5 cells. Br J Pharmacol. 1998;124:1541–1549.
• 5 Iwamuro Y, Miwa S, Zhang XF, Minowa T, Enoki T, Okamoto Y, et al. Activation of three types of voltage-independent Ca²⁺ channel in A7r5 cells by endothelin-1 as revealed by a novel Ca²⁺ channel blocker LOE 908. Br J Pharmacol. 1999;126:1107–1114.

Terms in the title (7)： ヒト ,  エンドセリン ,  受容体 ,  G12蛋白質 ,  カップリング ,  シグナリング ,  発現