Art

J-GLOBAL ID：201002228990277366   Reference number：10A1095590

Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation

ビタミンKは培養マクロファージ様細胞中でIKKα/βリン酸化の抑制を通して核因子κB活性化阻害によりリポ多糖類誘導炎症性サイトカイン発現を抑制する

Author (9)： OHSAKI Yusuke (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  SHIRAKAWA Hitoshi (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  MIURA Akihito (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  GIRIWONO Puspo E. (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  SATO Shoko (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  OHASHI Ai (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  IRIBE Maiko (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  GOTO Tomoko (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan) ,  KOMAI Michio (Lab. of Nutrition, Graduate School of Agricultural Sci., Tohoku Univ., Sendai 981-8555 Japan)
Material： Journal of Nutritional Biochemistry  (JNB)
Volume： 21  Issue： 11  Page： 1120-1126  Publication year： Nov. 2010 
JST Material Number： E0597B  ISSN： 0955-2863  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *vitamin K ,  *serine-threonine kinase ,  phosphorylation ,  *NF-kappaB ,  lipopolysaccharide ,  inflammatory cytokine ,  inflammation ,  *anti-inflammatory action ,  cell physiology ,  THP-1 cell ,  RAW264.7 cell ,  interleukin 6 ,  gene expression ,  macrophage ,  quinone ,  alicyclic compound ,  diene ,  polynuclear aromatic compound ,  polyene
Semi thesaurus term： *IKK alpha ,  *IKK beta ,  cell signaling

JST classification (3)： Other vitamins  (EB07070D) ,  Immunological reaction in general  (ED03010T) ,  Cell physiology in general  (EF02010S)

Substance index (2)： Menadione ,  Menatetrenone

Terms in the title (12)： ビタミンK ,  培養 ,  マクロファージ様細胞 ,  IKKα ,  リン酸化 ,  核因子κB ,  活性化 ,  阻害 ,  リポ多糖類 ,  誘導 ,  炎症性サイトカイン ,  発現