Art

J-GLOBAL ID：201002237645896435   Reference number：10A1144094

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF

スプリセオスタチンAはVEGFなどの包括的な遺伝子発現阻害により血管新生を遮断する

Author (9)： FURUMAI Ryohei (RIKEN, Saitama) ,  UCHIDA Kazuyo (RIKEN, Saitama) ,  KOMI Yusuke (RIKEN, Saitama) ,  YONEYAMA Misao (RIKEN, Saitama) ,  ISHIGAMI Ken (Univ. Tokyo, Tokyo) ,  WATANABE Hidenori (Univ. Tokyo, Tokyo) ,  KOJIMA Soichi (RIKEN, Saitama) ,  YOSHIDA Minoru (RIKEN, Saitama) ,  YOSHIDA Minoru (JST-CREST, Saitama, JPN)
Material： Cancer Science  (Cancer Sci)
Volume： 101  Issue： 11  Page： 2483-2489  Publication year： Nov. 2010 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： VEGF ,...
Semi thesaurus term： VEGF gene

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： FR-901464 ,  Spliceostatin A

Reference (28)：

• FERRARA, N. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004, 3, 5, 391-400
• CARMELIET, P. Angiogenesis in cancer and other diseases. Nature. 2000, 407, 6801, 249-257
• FOLKMAN, J. Anti-angiogenesis : new concept for therapy of solid tumors. Ann Surg. 1972, 175, 3, 409-416
• MATSUMOTO, T. VEGF receptor signal transduction. Sci STKE 2001. 2001, 112, RE21
• FERRARA, N. Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2009, 29, 6, 789-791

Terms in the title (6)： スプリセオスタチンA ,  VEGF ,  遺伝子発現 ,  阻害 ,  血管新生 ,  遮断