Art

J-GLOBAL ID：201002261516009781   Reference number：10A0232519

Design, synthesis, evaluation and QSAR analysis of N ¹-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

選択的ブチリルコリンエステラーゼ阻害剤としてのN1置換ノルシムセリン誘導体の設計,合成,評価およびQSAR解析

Author (12)： TAKAHASHI Jun (Dep. of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 ...) ,  HIJIKURO Ichiro (Dep. of Dev., ChemGenesis Inc., 4-10-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, JPN) ,  KIHARA Takeshi (Dep. of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 ...) ,  MURUGESH Modachur G. (Dep. of Dev., ChemGenesis Inc., 4-10-1 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, JPN) ,  FUSE Shinichiro (Dep. of Applied Chemistry, Graduate School of Sci. and Engineering, Tokyo Inst. of Technol., 2-12-1 Ookayama, Meguro ...) ,  KUNIMOTO Ryo (Dep. of Systems Bioscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 ...) ,  TSUMURA Yoshinori (Dep. of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 Yoshida-Shimoadachi-cho ...) ,  AKAIKE Akinori (Dep. of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 Yoshida-Shimoadachi-cho ...) ,  NIIDOME Tetsuhiro (Dep. of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 ...) ,  OKUNO Yasushi (Dep. of Systems Bioscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 ...) ,  TAKAHASHI Takashi (Dep. of Applied Chemistry, Graduate School of Sci. and Engineering, Tokyo Inst. of Technol., 2-12-1 Ookayama, Meguro ...) ,  SUGIMOTO Hachiro (Dep. of Neuroscience for Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto Univ., 46-29 ...)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 20  Issue： 5  Page： 1718-1720  Publication year： Mar. 01, 2010 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Terms in the title (7)： ブチリルコリンエステラーゼ ,  阻害剤 ,  置換 ,  誘導体 ,  設計 ,  評価 ,  QSAR解析