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J-GLOBAL ID：201002290598266752   Reference number：10A0107620

Effects of Maternal Exposure to Low Doses of DES on Testicular Steroidogenesis and Spermatogenesis in Male Rat Offspring

雄ラットの子における精巣ステロイド産生と精子形成に及ぼす低用量DESへの母体曝露の影響

Author (7)： KOBAYASHI Tetsuo (Dep. of Anatomy II, School of Veterinary Medicine, Azabu Univ.) ,  SHIRAI Mitsuyuki (Dep. of Veterinary Pharmacology, School of Veterinary Medicine, Azabu Univ.) ,  SAKAUE Motoharu (Dep. of Anatomy II, School of Veterinary Medicine, Azabu Univ.) ,  MURAKAMI Masaru (Dep. of Molecular Biology, School of Veterinary Medicine, Azabu Univ.) ,  OCHIAI Hideharu (Res. Inst. of Biosciences, Azabu Univ.) ,  ARISHIMA Kazuyoshi (Dep. of Anatomy II, School of Veterinary Medicine, Azabu Univ.) ,  YAMAMOTO Masako (Dep. of Anatomy II, School of Veterinary Medicine, Azabu Univ.)
Material： Journal of Reproduction and Development  (J Reprod Dev)
Volume： 55  Issue： 6  Page： 629-637 (J-STAGE)  Publication year： 2009 
JST Material Number： F0766A  ISSN： 0916-8818  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Rattus ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (3)： Sex hormones  (EB08050O) ,  Gene expression  (EC02040Q) ,  Reproductive(=genital)organs  (EJ15020P)

Substance index (2)： Diethylstilbestrol ,  Testosterone

Reference (56)：

• KEMPER, CH. Migration and proliferation of primordial germ cells in the rat. Teratology. 1987, 36, 117-124
• HAAVISTO, T. Prenatal testosterone and luteinizing hormone levels in male rats exposed during pregnancy to 2,3,7,8-tetrachlorodibenzo-p-dioxin and diethylstilbestrol. Mol Cell Endocrinol. 2001, 178, 169-179
• HAAVISTO, TE. Effect of 4-tertoctylphenol, 4-tert-butylphenol, and diethylstilbestrol on prenatal testosterone surge in the rat. Reprod Toxicol. 2003, 17, 593-605
• WARITA, K. Progress of the dose-related effects of estrogenic disruptors, an important factor in declining fertility, differs between the hypothalamic-pituitary axis and reproductive organs of male mice. J Vet Med Sci. 2006, 68, 1257-1267
• YAMAMOTO, M. Effects of maternal exposure to diethylstilbestrol on the development of the reproductive system and thyroid function in male and female rat offspring. J Toxicol Sci. 2003, 28, 385-394

Terms in the title (8)： ラット ,  子 ,  精巣 ,  ステロイド産生 ,  精子形成 ,  低用量 ,  DES ,  母体曝露