Art

J-GLOBAL ID：201002298211579635   Reference number：10A0036651

Structure-activity relationship of bile alcohols as human farnesoid X receptor agonist

ヒトファルネソイドX受容体作動薬としての胆汁アルコールの構造活性相関

Author (5)： IGUCHI Yusuke (Lab. of Organic and Bio-molecular Chemistry, Fac. of Pharmaceutical Sci., Hiroshima International Univ., 5-1-1 ...) ,  IGUCHI Yusuke (Div. of Clinical Pharmaceutical Sci., Programs for Pharmaceutical Sciences, Graduate School of Biomedical Sciences ...) ,  KIHIRA Kenji (Div. of Clinical Pharmaceutical Sci., Programs for Pharmaceutical Sciences, Graduate School of Biomedical Sciences ...) ,  NISHIMAKI-MOGAMI Tomoko (Div. of Biosignaling, National Inst. of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, JPN) ,  UNE Mizuho (Lab. of Organic and Bio-molecular Chemistry, Fac. of Pharmaceutical Sci., Hiroshima International Univ., 5-1-1 ...)
Material： Steroids  (Steroids. Structure, Function and Regulation)
Volume： 75  Issue： 1  Page： 95-100  Publication year： Jan. 2010 
JST Material Number： C0103B  ISSN： 0039-128X  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *drug ,  human ,  Structure-Activity Relationship ,  bile acid ,  *sterol ,  alicyclic alcohol ,  polyol ,  aliphatic alcohol ,  side chain ,  luciferase ,  bioassay ,  gene manipulation ,  emission spectrometry ,  Bile ,  hydroxy group ,  *Farnesoid X Receptor ,  luciferase assay ,  *cytosol receptor
Semi thesaurus term： *cytosol receptor ,  hydroxyl group ,  agonist

JST classification (3)： Steroids  (CF10040O) ,  Receptors on cell membrane  (EF04030C) ,  Biochemistry of lipids in general  (EB05010B)

Substance index (19)： (22S)-5β-Cholestane-3α,7α,12α,22-tetraol ,  (22R)-5β-Cholestane-3α,7α,12α,22-tetraol ,  (23S)-5β-Cholestane-3α,7α,12α,23-tetraol ,  (23R)-5β-Cholestane-3α,7α,12α,23-tetraol ,  (24S)-5β-Cholestane-3α,7α,12α,24-tetraol ,  (24R)-5β-Cholestane-3α,7α,12α,24-tetraol ,  5β-Cholestane-3α,7α,12α,25-tetrol ,  5β-Cholestane-3α,7α,12α,27-tetrol ,  24-Nor-5β-cholane-3α,7α,12α,23-tetraol ,  5β-Petromyzonol ,  26,27-Dinor-5β-cholestane-3α,7α,12α,25-tetraol ,  27-Nor-5β-cholestane-3α,7α,12α,26-tetraol ,  5β-Cyprinol ,  5β-Cholestane-3α,7α,26,27-tetraol ,  5β-Cholestane-3α,7α,26-triol ,  5α-Cyprinol ,  5α-Cholestane-3α,7α,12α,26-tetraol ,  5α-Cholestane-3α,7α,26,27-tetraol ,  5α-Cholestane-3α,7α,26-triol

Terms in the title (6)： ヒト ,  ファルネソイドX受容体 ,  作動薬 ,  胆汁 ,  アルコール ,  構造活性相関