Research keywords (7)：
neurodegeneration
, Alzheimer disease
, γ-secretase
, presenilin
, amyloid β-protein
, tau
, lipid
Research theme for competitive and other funds (3)：
2022 - 2025 Effect of Alzheimer associated presenilin dysfunction on cholesterol metabolism in human neuron
2017 - 2021 Role of gamma-secretase in cellular cholesterol metabolism
2010 - 2011 The impact of clinical presenilin mutations on amyloid formation in the brains of familial Alzheimer disease
Papers (10)：
Marietta Fabiano, Naoto Oikawa, Anja Kerksiek, Jun-ichi Furukawa, Hirokazu Yagi, Koichi Kato, Ulrich Schweizer, Wim Annaert, Jongkyun Kang, Jie Shen, et al. Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function. International Journal of Molecular Sciences. 2024. 25. 10. 5417-5417
Naoto Oikawa, Marietta Fabiano, Ulrike C. Müller, Jochen Walter. Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition. Biochemical and Biophysical Research Communications. 2021. 570. 137-142
Esteban Gutierrez, Dieter Lütjohann, Anja Kerksiek, Marietta Fabiano, Naoto Oikawa, Lars Kuerschner, Christoph Thiele, Jochen Walter. Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism. Life science alliance. 2020. 3. 6
Presenilin deficiency increases cholesterol by protein glycosylation impairment
(2021)
Gamma-secretase inhibition induces lipid droplet accumulation via APP-CTF accumulation
(Alzheimer's Association International Conference 2018 2018)
γ-Secretase in the regulation of autophagy and cellular cholesterol metabolism
(Termination symposium, The Collaborative Research Center SFB 645 “Regulation and manipulation of information flow within dynamic protein and lipid environments” 2016)
Hsp70 rescues mutant tau-induced neurodegeneration in C. elegans
(2006)
Education (3)：
2006 - 2010 Shinshu University Graduate School of Medicine
2004 - 2006 The University of Tokyo Graduate School of Medicine Medical Science
2000 - 2004 Tottori University Faculty of Medicine School of Life Science
Professional career (1)：
Ph.D. (Medical Science)
Work history (4)：
2021/07 - 現在 Hokkaido University
2020/08 - 2021/06 Shiga University of Medical Science Molecular Neuroscience Research Center Special Contract Assistant Professor
2015/04 - 2020/07 University of Bonn Department of Neurology Research Fellow
2010/04 - 2015/03 National Center for Geriatrics and Gerontrogy Center for Development of Advanced Medicine for Dementia Research Fellow
Committee career (2)：
2023 - 現在 日本認知症学会 広報委員会若手小委員会委員
2013 - 2014 日本認知症学会 若手研究者委員
Awards (1)：
2020/03 - American Society for Biochemistry and Molecular Biology 2020 ASBMB Travel Award Implication of protein glycolsylation impairment in celluar cholesterol accumulation caused by Presenilin deficiency
Association Membership(s) (2)：
The Japanese Society for Neurochemistry
, Japan Society for Dementia Research
