2021 - 2024 APEX multi-labels, large field 3D electron microscopy analysis for highly dense brain networks
2020 - 2024 Establishment of animal disease models for intractable pediatric diseases due to defects of RNA metabolism and development of new therapeutics
2021 - 2023 認知学習と精神疾患病態の臨界期におけるドーパミン神経伝達機構の解析
2018 - 2021 Analysis of basal ganglia circuit mechanisms in cognitive learning and psychiatric disorders
2018 - 2021 Physiological functions in stress response and cognitive function of Neuromedin U system
2016 - 2021 Neuronal circuit mechanisms of reward/goal-directed behavior
2016 - 2019 The roles of importin-alpha subfamilies in mammals
2016 - 2019 Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders
2016 - 2019 Neuronal circuit mechanisms in prepulse inhibition
2015 - 2019 Basal ganglia circuit mechanisms in cognitive behavior and neuropsychiatric pathology
2015 - 2017 Elucidation of interaction between regulation of food intake and brain reward system to understand over-eating
2014 - 2017 Elucidation of the role of the depression of nucleocytoplasmic transport relative factor for neuropsychiatric disorder
2011 - 2016 Regulatory mechanisms of reward, aversivion, and decision-making
2011 - 2016 Elucidation of the Neral Computation for Prediction and Decision Making
2011 - 2015 Regulatory mechanism of basal ganglia circuit in reward and aversive behavior and decision-making
2010 - 2012 Research for therapeutic application of dominant negative GAPDH molecule on oxidative stress-induced disorder
2009 - 2012 運動・精神機能を司る大脳基底核神経回路の制御機構
2011 - 2011 可逆的神経伝達阻止法を用いた大脳基底核ニューロサーキットパソロジーの解析
2010 - 2011 Neural mechanism of basal gangIia circuit in drug addiction
2008 - 2009 Molecular pathophysiology of drug addiction in the basal ganglia network
2005 - 2009 Studies on molecular mechanisms that control development and function of the neural network
2006 - 2007 大脳基底核神経回路における薬物依存の分子機構
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Papers (113)：
Jonghyuk Park, Hiroko Shimbo, Shoko Tamura, Toshifumi Tomoda, Takatoshi Hikida, Haruo Okado, Shinobu Hirai. Impact of feeding age on cognitive impairment in mice with Disrupted-In-Schizophrenia 1 (Disc1) mutation under a high sucrose diet. Behavioural Brain Research. 2025. 476. 115291-115291
Koki Sakurai, Makiko Morita, Yoshiatsu Aomine, Mitsunobu Matsumoto, Tetsuji Moriyama, Emiko Kasahara, Atsuo Sekiyama, Mayumi Otani, Rieko Oshima, Kate L Loveland, et al. Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice. Translational psychiatry. 2024. 14. 1. 426-426
Yuuki Uchida, Takatoshi Hikida, Manabu Honda, Yuichi Yamashita. Heterogeneous Appetite Patterns in Depression: Computational Modeling of Nutritional Interoception, Reward Processing, and Decision-Making. bioRxiv. 2024
Yoshiatsu Aomine, Yuto Shimo, Koki Sakurai, Mayuka Abe, Tom Macpherson, Takaaki Ozawa, Takatoshi Hikida. Sex-dependent differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice. Journal of neurochemistry. 2024
Yoshiatsu Aomine, Yuto Shimo, Koki Sakurai, Mayuka Abe, Tom Macpherson, Takaaki Ozawa, Takatoshi Hikida. Sex-dependant differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice. bioRxiv. 2024
Neural circuit mechanisms in decision-making of model mice.
(UK-Japan Hikikomori Research Workshop 2024 2024)
An approach for pathophysiology of mental disorders from neural circuit mechanisms of decision-making behavior
(Annual meeting of Physiology Society of Japan 2024)
1998 - 2002 Kyoto University Graduate School of Medicine
1991 - 1997 Kyoto University Faculty of Medicine
Work history (8)：
2017/04 - 現在 Osaka University Institute for Protein Research Professor
2011/10 - 2017/03 Kyoto University Graduate School of Medicine Associate Professor
2011/10 - 2015/03 Osaka Bioscience Institute Visiting Scientist
2009/10 - 2013/03 JST, PRESTO Researcher
2005/09 - 2011/09 Osaka Bioscience Institute Reseach Associate
2003/04 - 2005/08 Johns Hopkins University School of Medicine Postdoctoral Fellow
2002/04 - 2003/03 Kyoto University School of Medicine Postdoctoral Researcher
2002/03 - Kyoto University MD., PhD.
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Awards (8)：
2017/09 - Japanese Society of Neuropsychopharmacology Young Investigator Award neuronal circuit mechanisms in cognitive learning and psychiatric disorders
2016/09 - JSBP JSBP Young Investigator Program Most Encouragement Award
2014/09 - JSBP Young Investigator Award
2014/06 - JSNP JSNP Excellent Presentation Award for CINP 2014
2012/09 - Japanese Society of Biological Psychiatry Young Investigater Award Regulatory mechanisms of basal ganglia circuit in decision-making and drug addiction
2011/09 - Japan Neuroscience Society Young Investigator Award Regulatory mechanism of basal ganglia circuit
2010/07 - 包括脳科学研究推進支援ネットワーク、日本神経科学学会 平成22年度包括脳ネットワーク若手優秀発表賞 Distinct roles of synaptic transmission in the direct and indirect striatal pathways to reward and aversive behavior
2009/05 - Osaka Bioscience Institute Hayaishi encouragement award
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Association Membership(s) (8)：
日本精神神経学会
, PHYSIOLOGICAL SOCIETY OF JAPAN
, Japanese Society of Schizophrenia Research
, THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY
, Society for Neuroscience
, THE JAPAN NEUROSCIENCE SOCIETY
