Naoki Umemura

ウメムラナオキ | Naoki Umemura

Affiliation and department：
Job title：講師

Research field (4)： Surgical dentistry , Conservative dentistry and endodontics , Pharmacology , Oral medicine

Research keywords (2)：歯髄幹細胞 , 多血小板血漿

Research theme for competitive and other funds (15)：

2022 - 2025 Modification of the intercellular network of immune cells in tumor microenvironment by sedatives and anesthetics.
2021 - 2024 化学療法抵抗性の頭頸部腫瘍を伴う患者でニボルマブが化学療法を著効する仕組みの解明
2020 - 2023 口腔扁平上皮癌の悪性化に伴う間葉系および骨髄系間質細胞の免疫制御と調節因子の変化
2020 - 2023 歯髄幹細胞の象牙芽細胞への分化誘導メカニズムの歯科臨床応用
2018 - 2022 Effect of low-dose / low-dose-rate radiation on systemic immunity of disease model animals

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Papers (42)：

Swagatika Das, Praveen K. Roayapalley, Hiroshi Sakagami, Naoki Umemura, Dennis K. J. Gorecki, Mohammad Hossain, Masami Kawase, Umashankar Das, Jonathan R. Dimmock. Dimeric 3,5-Bis(benzylidene)-4-piperidones: Tumor-Selective Cytotoxicity and Structure-Activity Relationships. Medicines. 2024. 11. 1. 3-3
Daisuke Yokokawa, Naoki Umemura, Yuka Miyamoto, Nobuo Kondoh, Satoshi Kawano. Chemokine-like receptor 1-positive cells are present in the odontoblast layer in tooth tissue in rats and humans. Experimental and Therapeutic Medicine. 2023. 27. 2
Koichi Murakami, Naoki Umemura, Makoto Adachi, Masahiro Motoki, Emika Ohkoshi. ABCG2, CD44 and SOX9 are increased with the acquisition of drug resistance and involved in cancer stem cell activities in head and neck squamous cell carcinoma cells. Experimental and therapeutic medicine. 2022. 24. 6. 722-722
Kenichi Nonaka, Masanao Saio, Naoki Umemura, Arizumi Kikuchi, Takao Takahashi, Shinji Osada, Kazuhiro Yoshida. Th1 polarization in the tumor microenvironment upregulates the myeloid-derived suppressor-like function of macrophages. Cellular immunology. 2021. 369. 104437-104437
Mohamed A A Orabi, Hiroshi Sakagami, Naoki Umemura, Hamad S Alyami, Tsutomu Hatano. Two new C-glycosidic ellagitannins and accompanying tannins from Lawsonia inermis leaves and their cytotoxic effects. Fitoterapia. 2021. 153. 104925-104925

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MISC (26)：

岸田皐, 梅村直己, 宮崎裕美, 水野憲一, 大越絵実加. Induction of necroptotic cell death using naphthoquinone derivatives on multidrug resistant oral squamous cell carcinoma. 日本薬学会年会要旨集(Web). 2022. 142nd
梅村直己, 上野恭平, 高山英次, 川木晴美, 近藤信夫. Maintenance of cancer stem cell characteristic in oral squamous cell carcinoma cells by the expression of ABCG2 associated with acquired drug resistance. Journal of Oral Biosciences Supplement (Web). 2021. 2021
今藍理, 梅村直己, 宮崎裕美, 大越絵実加. Induction of necroptotic cell death using naphthoquinone derivatives on multidrug resistant head and neck squamous cell carcinoma. 日本薬学会年会要旨集(Web). 2021. 141st
神谷真子, 高山英次, 川木晴美, 梅村直己, 上野恭平, 高橋萌, 智原栄一, 村松泰徳, 近藤信夫. Effect of midazolam on the IL-10 production in stimulated mouse splenocytes. Journal of Oral Biosciences Supplement (Web). 2021. 2021
安藤恵, 神谷真子, 池野久美子, 上野恭平, 梅村直己, 高山英治, 川木晴美, 中村源次郎, 近藤信夫. Regulation of cytokine production from anti CD3-stimulated mouse spleen cells by Chinese propolis. Journal of Oral Biosciences Supplement (Web). 2021. 2021

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Education (2)：

2004 - 2008 Gifu university school of medicine
- 2002 Aichi-gakuin university School of dentistry

Professional career (1)：

Ph.D (Gifu university)

Work history (3)：

2014 - Meikai University School of Dentistry
2011/04 - Meikai University School of dentistry assistant professor
2009/04 - 2011/03 University of Pittsburgh research associate

Committee career (2)：

2020/10 - 現在 Oncology Reports (Spandidos publications) Editorial Board member
2020/04 - 現在 Molecular Medicne Reports (Spandidos publications) Editorial Board member

Awards (1)：

2008/10 - The 10th International Symposium on Dendritic Cells poster award

Association Membership(s) (5)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , JAPANESE STOMATOLOGICAL SOCIETY , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE PHARMACOLOGICAL SOCIETY , JAPANESE ASSOCIATION FOR ORAL BIOLOGY

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