Okamoto Hitoshi

オカモトヒトシ | Okamoto Hitoshi

Affiliation and department：
Job title： Visiting Senior Scientist
Other affiliations (2)：

RIKEN Center for Brain Science Visiting Senior Scientist
Institute of Neuropsychiatry visiting scientist

Homepage URL (2)： https://cbs.riken.jp/jp/faculty/f.kubo/index.html , https://www.hitoshi-okamoto-research.com

Research field (2)： Developmental biology , Neuroscience - general

Research keywords (42)： telencephalon , avoidance , reward , active inference , prediction error , interoception , left-right asymmetry , cortico-basal ganglia loop , social conflict , decision-making , 包括脳ネットワーク , 統合脳・神経回路機能 , カルシウムイメージング , HNK-1 , 迷走運動神経 , Isl-1遺伝子 , Apterous , ノッチシグナル , ディファレンシャルディスプレイ , zebrafish , 手綱核 , 細胞移動 , 中脳分化 , ホメオドメイン蛋白 , homeodomain , Isl-1 , 視蓋 , 小脳分化 , ディファレンシャルディスプレー , 神経細胞分化 , サブトラクション , 中脳後脳境界 , LH2 , 運動神経細胞 , 小脳 , トランスジェニック , 中脳 , 中脳・後脳境界部 , 運命決定 , Islet-3 , LIM , ゼブラフィッシュ

Research theme for competitive and other funds (38)：

2023 - 2028 Control mechanisms of decision-making behavior based on transduction of prediction and prediction error signals between hierarchical brain regions.
2021 - 2025 Study of the switching regulation of social and cognitive behaviors by the habenula-interpeduncular nucleus pathway
2016 - 2021 Neural circuit mechanisms for regulation of social conflicts
2016 - 2019 社会的闘争を制御する神経回路機構
2011 - 2016 Elucidation of the Neral Computation for Prediction and Decision Making

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Papers (158)：

Yuki Tanimoto, Hisaya Kakinuma, Ryo Aoki, Toshiyuki Shiraki, Shin-Ichi Higashijima, Hitoshi Okamoto. Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish. Cell reports. 2024. 113916-113916
Kotaro Shibayama, Haruna Nakajo, Yuki Tanimoto, Hisaya Kakinuma, Toshiyuki Shiraki, Takashi Tsuboi, Hitoshi Okamoto. The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish. Neuroscience research. 2024
Masae Kinoshita, Hitoshi Okamoto. Acetylcholine potentiates glutamate transmission from the habenula to the interpeduncular nucleus in losers of social conflict. Current Biology. 2023
Yoshiro Yonezawa, Long Guo, Hisaya Kakinuma, Nao Otomo, Soichiro Yoshino, Kazuki Takeda, Masahiro Nakajima, Toshiyuki Shiraki, Yoji Ogura, Yohei Takahashi, et al. Identification of a functional susceptibility variant for adolescent idiopathic scoliosis that upregulates EGR1-mediated UNCX expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022. 38. 1. 144-153
Makio Torigoe, Tanvir Islam, Hisaya Kakinuma, Chi Chung Alan Fung, Takuya Isomura, Hideaki Shimazaki, Tazu Aoki, Tomoki Fukai, Hitoshi Okamoto. Zebrafish capable of generating future state prediction error show improved active avoidance behavior in virtual reality. Nature Communications. 2021. 12. 1

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MISC (98)：

岡本仁, 青木田鶴, 天羽龍之介. 適応的危険回避プログラムは,脳でどのように書き込まれるのか? : ゼブラフィッシュを用いた研究 (特集こころの動物モデル : サカナからサルまで). 分子精神医学. 2016. 16. 2. 74-83
Hitoshi Okamoto. Neurobiology: Sensory Lateralization in the Fish Brain. CURRENT BIOLOGY. 2014. 24. 7. R285-R287
Michihiro Mieda, Emi Hasegawa, Hitoshi Okamoto, Takeshi Sakurai. Roles of AVP-producing neurons in the central circadian pacemaker of the suprachiasmatic nucleus. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S258-S258
Hidenori Aizawa, Shin Yanagihara, Megumi Kobayashi, Kazue Niisato, Takashi Takekawa, Rie Harukuni, Thomas McHugh, Tomoki Fukai, Yoshikazu Isomura, Hitoshi Okamoto. The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation. Journal of Neuroscience. 2013. 33. 20. 8909-8921
大畑慎也, 岡本仁. 神経上皮細胞の頂底極性制御因子Crb・Moe複合体 (特集細胞極性の制御). 生体の科学. 2012. 63. 3. 171-176

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Books (4)：

現代生物科学入門,第4巻
岩波書店 2009
シリーズ脳科学、脳の発生と発達(岡本仁編)
東京大学出版会 2008
脳科学の最前線(上巻、脳と認知と進化)、理化学研究所、脳科学総合研究センター編
講談社ブルーバックス 2007
脳科学の進歩、〜分子から心まで〜
大学教育振興会 2006

Professional career (2)：

MD (The University of Tokyo)
理学博士 (東京大学)

Work history (30)：

2024/08 - 現在 Waseda University Faculty of Science and Engineering Senior ZVisiting Scientist
2024/04 - 現在 Institute of Neuropsychiatry visiting scientist
2024/04 - 現在 RIKEN Center for Brain Science Visiting Senior Scientist
2024/04 - 2024/07 Waseda University Faculty of Science and Engineering visiting scientists
2018/04 - 2024/03 RIKEN Center for Brain Science

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Awards (1)：

1914/07 - Japanese Society for Neuroscience Tokizane Prize

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