Art

J-GLOBAL ID：201102217776086087   Reference number：11A0128677

OSU-03012, a novel celecoxib derivative, induces cell swelling and shortens action potential duration in mouse ventricular cells

OSU-03012,新規セレコキシブ誘導体は細胞膨張を誘発して,マウス心室細胞の活動電位持続時間を短縮する

Author (5)： YAMAMOTO Shintaro (Dep. of Pharmacology, School of Medicine, Fukuoka Univ., Fukuoka, JPN) ,  IYODA Takuya (Dep. of Pharmacology, School of Medicine, Fukuoka Univ., Fukuoka, JPN) ,  KITA Satomi (Dep. of Pharmacology, School of Medicine, Fukuoka Univ., Fukuoka, JPN) ,  YAMADA Toshiki (Dep. of Pharmacology, School of Medicine, Fukuoka Univ., Fukuoka, JPN) ,  IWAMOTO Takahiro (Dep. of Pharmacology, School of Medicine, Fukuoka Univ., Fukuoka, JPN)
Material： Biomedical Research  (Biomed Res)
Volume： 31  Issue： 6  Page： 413-417 (J-STAGE)  Publication year： 2010 
JST Material Number： Z0236B  ISSN： 0388-6107  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Cardiac Myocyte ,...
Semi thesaurus term： action potential duration ,...

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JST classification (2)： Poisoning in general  (GD06010Q) ,  Heart  (EJ04020D)

Substance index (2)： Glibenclamide ,  OSU-03012

Reference (22)：

• 1. Al-Dadah AS, Voeller RK, Schuessler RB, Damiano RJ, Jr. and Lawton JS (2007) Maintenance of myocyte volume homeostasis during stress by diazoxide is cardioprotective. Ann Thorac Surg 84, 857-862.
• 2. Billman GE (2008) The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy. Pharmacol Ther 120, 54-70.
• 3. Budas GR, Sukhodub A, Alessi DR and Jovanovic A (2006) 3´Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium. FASEB J 20, 2556-2558.
• 4. Ceci M, Ross J, Jr. and Condorelli G (2004) Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: a focus on AKT. J Mol Cell Cardiol 37, 905-912.
• 5. Drewnowska K and Baumgarten CM (1991) Regulation of cellular volume in rabbit ventricular myocytes: bumetanide, chlorothiazide, and ouabain. Am J Physiol 260, C122-131.

Terms in the title (8)： OSU-03012 ,  セレコキシブ ,  誘導体 ,  細胞膨張 ,  誘発 ,  マウス ,  心室細胞 ,  活動電位持続時間