Art
J-GLOBAL ID：201102224553174339   Reference number：11A1931363

Water-Soluble Prodrug of Antimicrotubule Agent Plinabulin: Effective Strategy with Click Chemistry

抗微小管剤プリナブリンの水溶性プロドラッグ クリックケミストリーによる効果的な方法
Author (6)：
YAKUSHIJI Fumika

About YAKUSHIJI Fumika

(Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)

About Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN

, 
TANAKA Hironari

About TANAKA Hironari

(Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)

About Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN

, 
MUGURUMA Kyohei

About MUGURUMA Kyohei

(Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)

About Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN

, 
IWAHASHI Takahiro

About IWAHASHI Takahiro

(Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)

About Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN

, 
YAMAZAKI Yuri

About YAMAZAKI Yuri

(Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)

About Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN

, 
HAYASHI Yoshio

About HAYASHI Yoshio

(Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)

About Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN


Material：
Chemistry - European Journal  (Chem Eur J)

About Chemistry - European Journal


Volume： 17  Issue： 45  Page： 12587-12590  Publication year： 2011 
JST Material Number： W0744A  ISSN： 0947-6539  CODEN： CEUJED  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*antitumor drug

About antitumor drug

, 
*nitrogen heterocyclic compound

About nitrogen heterocyclic compound

, 
water solubility

About water solubility

, 
prodrug

About prodrug

, 
chemical synthesis

About chemical synthesis

, 
Aspergillus

About Aspergillus


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
click chemistry

About click chemistry

, 
*Diketopiperazines

About Diketopiperazines

, 
プリナブリン

About プリナブリン


JST classification (2)：
JST classification
Category name(code) classified by JST.
Pyrazines 
(CF07104N)

About Pyrazines

,  Basic research of antitumor(=antineoplastic)drugs 
(GW16010A)

About Basic research of antitumor(=antineoplastic)drugs

Substance index (7)：
Substance index
Chemical Substance indexed to the Article.
(-)-Phenylahistin

About (-)-Phenylahistin

, 
NPI-2358

About NPI-2358

, 
5-Hexynoic acid chloromethyl ester

About 5-Hexynoic acid chloromethyl ester

, 
3-Benzylidene-5-(5-hexynoyloxymethoxy)-6-(5-tert-butyl-1H-imidazole-4-ylmethylene)-1,2,3,6-tetrahydropyrazine-2-one

About 3-Benzylidene-5-(5-hexynoyloxymethoxy)-6-(5-tert-butyl-1H-imidazole-4-ylmethylene)-1,2,3,6-tetrahydropyrazine-2-one

, 
(S)-2-Azido-3-hydroxypropanoic acid

About (S)-2-Azido-3-hydroxypropanoic acid

, 
(S)-2-[4-[4-Oxo-4-[3-(5-tert-butyl-1H-imidazole-4-ylmethylene)-5-oxo-6-benzylidene-3,4,5,6-tetrahydropyrazine-2-yloxymethoxy]butyl]-1H-1,2,3-triazole-1-yl]-3-hydroxypropanoic acid

About (S)-2-[4-[4-Oxo-4-[3-(5-tert-butyl-1H-imidazole-4-ylmethylene)-5-oxo-6-benzylidene-3,4,5,6-tetrahydropyrazine-2-yloxymethoxy]butyl]-1H-1,2,3-triazole-1-yl]-3-hydroxypropanoic acid

, 
(S)-2-[4-[4-Oxo-4-[3-(5-tert-butyl-1H-imidazole-4-ylmethylene)-5-oxo-6-benzylidene-3,4,5,6-tetrahydropyrazine-2-yloxymethoxy]butyl]-1H-1,2,3-triazole-1-yl]-3-hydroxypropanoic acid sodium salt

About (S)-2-[4-[4-Oxo-4-[3-(5-tert-butyl-1H-imidazole-4-ylmethylene)-5-oxo-6-benzylidene-3,4,5,6-tetrahydropyrazine-2-yloxymethoxy]butyl]-1H-1,2,3-triazole-1-yl]-3-hydroxypropanoic acid sodium salt

Terms in the title (5)：
Terms in the title
Keywords automatically extracted from the title.
微小管

About 微小管

, 
プリナブリン

About プリナブリン

, 
水溶性

About 水溶性

, 
プロドラッグ

About プロドラッグ

, 
クリックケミストリー

About クリックケミストリー


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